Polymorphisms in hypocretin/orexin pathway genes and narcolepsy

B. R. Ólafsdóttir; D. B. Rye; T. E. Scammell; J. K. Matheson; K. Stefánsson; J. R. Gulcher

doi:10.1212/WNL.57.10.1896

Polymorphisms in hypocretin/orexin pathway genes and narcolepsy

B. R. Ólafsdóttir, D. B. Rye, T. E. Scammell, J. K. Matheson, K. Stefánsson, J. R. Gulcher^*

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The neuroexcitatory peptide hypocretin and its receptors are central to the pathophysiology of both human and animal models of the disease. In this study of American and Icelandic patients with narcolepsy, the authors found no significant association between narcolepsy and single-nucleotide polymorphisms in the genes for hypocretin or its two known receptors, hypocretin receptor-1 and hypocretin receptor-2.

Original language	English
Pages (from-to)	1896-1899
Number of pages	4
Journal	Neurology
Volume	57
Issue number	10
DOIs	https://doi.org/10.1212/WNL.57.10.1896
Publication status	Published - 27 Nov 2001

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title = "Polymorphisms in hypocretin/orexin pathway genes and narcolepsy",

abstract = "The neuroexcitatory peptide hypocretin and its receptors are central to the pathophysiology of both human and animal models of the disease. In this study of American and Icelandic patients with narcolepsy, the authors found no significant association between narcolepsy and single-nucleotide polymorphisms in the genes for hypocretin or its two known receptors, hypocretin receptor-1 and hypocretin receptor-2.",

author = "{\'O}lafsd{\'o}ttir, {B. R.} and Rye, {D. B.} and Scammell, {T. E.} and Matheson, {J. K.} and K. Stef{\'a}nsson and Gulcher, {J. R.}",

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AU - Ólafsdóttir, B. R.

AU - Rye, D. B.

AU - Scammell, T. E.

AU - Matheson, J. K.

AU - Stefánsson, K.

AU - Gulcher, J. R.

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AB - The neuroexcitatory peptide hypocretin and its receptors are central to the pathophysiology of both human and animal models of the disease. In this study of American and Icelandic patients with narcolepsy, the authors found no significant association between narcolepsy and single-nucleotide polymorphisms in the genes for hypocretin or its two known receptors, hypocretin receptor-1 and hypocretin receptor-2.

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Polymorphisms in hypocretin/orexin pathway genes and narcolepsy

Abstract

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