Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction

Gunnar W. Reginsson; Andrés Ingason; Jack Euesden; Gyda Bjornsdottir; Sigurgeir Ólafsson; Engilbert Sigurdsson; Högni Óskarsson; Þórarinn Tyrfingsson; Valgerður Rúnarsdóttir; Ingunn Hansdóttir; Stacy Steinberg; Hreinn Stefánsson; Daniel Gudbjartsson; Thorgeir Thorgeirsson; Kari Stefansson; Hogni Oskarsson; Thorarinn Tyrfingsson; Valgerdur Runarsdottir

doi:10.1111/adb.12496

Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction

Gunnar W. Reginsson, Andrés Ingason, Jack Euesden, Gyda Bjornsdottir, Sigurgeir Ólafsson, Engilbert Sigurdsson, Högni Óskarsson, Þórarinn Tyrfingsson, Valgerður Rúnarsdóttir, Ingunn Hansdóttir, Stacy Steinberg, Hreinn Stefánsson, Daniel Gudbjartsson, Thorgeir Thorgeirsson, Kari Stefansson, Hogni Oskarsson, Thorarinn Tyrfingsson, Valgerdur Runarsdottir

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 10 036 individuals admitted for in‐patient addiction treatment and 35 754 smokers, we find that diagnoses of various substance use disorders and smoking associate strongly with PRSs for SCZ (P = 5.3 × 10−50–1.4 × 10−6) and BPD (P = 1.7 × 10−9–1.9 × 10−3), showing shared genetic etiology between psychosis and addiction. Using standardized scores for SCZ and BPD scaled to a unit increase doubling the risk of the corresponding disorder, the odds ratios for alcohol and substance use disorders range from 1.19 to 1.31 for the SCZ‐PRS, and from 1.07 to 1.29 for the BPD‐PRS. Furthermore, we show that as regular smoking becomes more stigmatized and less prevalent, these biological risk factors gain importance as determinants of the behavior.

Original language	English
Pages (from-to)	485-492
Journal	Addiction Biology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1111/adb.12496
Publication status	Published - 23 Feb 2017

Other keywords

Polygenic scores
Psychotic disorders
Substance abuse
Fíkn
Tóbaksnotkun
Áfengissýki
Fíkniefnaneysla
Geðklofi
Geðhvarfasýki
Geðsjúkdómar
Gen
PSY12
Multifactorial Inheritance
Mental Disorders
Substance-Related Disorders

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10.1111/adb.12496

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Reginsson, G. W., Ingason, A., Euesden, J., Bjornsdottir, G., Ólafsson, S., Sigurdsson, E., Óskarsson, H., Tyrfingsson, Þ., Rúnarsdóttir, V., Hansdóttir, I., Steinberg, S., Stefánsson, H., Gudbjartsson, D., Thorgeirsson, T., Stefansson, K., Oskarsson, H., Tyrfingsson, T., & Runarsdottir, V. (2017). Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction. Addiction Biology, 23(1), 485-492. https://doi.org/10.1111/adb.12496

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title = "Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction",

abstract = "We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 10 036 individuals admitted for in‐patient addiction treatment and 35 754 smokers, we find that diagnoses of various substance use disorders and smoking associate strongly with PRSs for SCZ (P = 5.3 × 10−50–1.4 × 10−6) and BPD (P = 1.7 × 10−9–1.9 × 10−3), showing shared genetic etiology between psychosis and addiction. Using standardized scores for SCZ and BPD scaled to a unit increase doubling the risk of the corresponding disorder, the odds ratios for alcohol and substance use disorders range from 1.19 to 1.31 for the SCZ‐PRS, and from 1.07 to 1.29 for the BPD‐PRS. Furthermore, we show that as regular smoking becomes more stigmatized and less prevalent, these biological risk factors gain importance as determinants of the behavior.",

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author = "Reginsson, {Gunnar W.} and Andr{\'e}s Ingason and Jack Euesden and Gyda Bjornsdottir and Sigurgeir {\'O}lafsson and Engilbert Sigurdsson and H{\"o}gni {\'O}skarsson and {\TH}{\'o}rarinn Tyrfingsson and Valger{\dh}ur R{\'u}narsd{\'o}ttir and Ingunn Hansd{\'o}ttir and Stacy Steinberg and Hreinn Stef{\'a}nsson and Daniel Gudbjartsson and Thorgeir Thorgeirsson and Kari Stefansson and Hogni Oskarsson and Thorarinn Tyrfingsson and Valgerdur Runarsdottir",

year = "2017",

month = feb,

day = "23",

doi = "10.1111/adb.12496",

language = "English",

volume = "23",

pages = "485--492",

journal = "Addiction Biology",

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Reginsson, GW, Ingason, A, Euesden, J, Bjornsdottir, G, Ólafsson, S, Sigurdsson, E, Óskarsson, H, Tyrfingsson, Þ, Rúnarsdóttir, V, Hansdóttir, I, Steinberg, S, Stefánsson, H, Gudbjartsson, D, Thorgeirsson, T, Stefansson, K, Oskarsson, H, Tyrfingsson, T & Runarsdottir, V 2017, 'Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction', Addiction Biology, vol. 23, no. 1, pp. 485-492. https://doi.org/10.1111/adb.12496

TY - JOUR

T1 - Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction

AU - Reginsson, Gunnar W.

AU - Ingason, Andrés

AU - Euesden, Jack

AU - Bjornsdottir, Gyda

AU - Ólafsson, Sigurgeir

AU - Sigurdsson, Engilbert

AU - Óskarsson, Högni

AU - Tyrfingsson, Þórarinn

AU - Rúnarsdóttir, Valgerður

AU - Hansdóttir, Ingunn

AU - Steinberg, Stacy

AU - Stefánsson, Hreinn

AU - Gudbjartsson, Daniel

AU - Thorgeirsson, Thorgeir

AU - Stefansson, Kari

AU - Oskarsson, Hogni

AU - Tyrfingsson, Thorarinn

AU - Runarsdottir, Valgerdur

PY - 2017/2/23

Y1 - 2017/2/23

N2 - We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 10 036 individuals admitted for in‐patient addiction treatment and 35 754 smokers, we find that diagnoses of various substance use disorders and smoking associate strongly with PRSs for SCZ (P = 5.3 × 10−50–1.4 × 10−6) and BPD (P = 1.7 × 10−9–1.9 × 10−3), showing shared genetic etiology between psychosis and addiction. Using standardized scores for SCZ and BPD scaled to a unit increase doubling the risk of the corresponding disorder, the odds ratios for alcohol and substance use disorders range from 1.19 to 1.31 for the SCZ‐PRS, and from 1.07 to 1.29 for the BPD‐PRS. Furthermore, we show that as regular smoking becomes more stigmatized and less prevalent, these biological risk factors gain importance as determinants of the behavior.

AB - We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 10 036 individuals admitted for in‐patient addiction treatment and 35 754 smokers, we find that diagnoses of various substance use disorders and smoking associate strongly with PRSs for SCZ (P = 5.3 × 10−50–1.4 × 10−6) and BPD (P = 1.7 × 10−9–1.9 × 10−3), showing shared genetic etiology between psychosis and addiction. Using standardized scores for SCZ and BPD scaled to a unit increase doubling the risk of the corresponding disorder, the odds ratios for alcohol and substance use disorders range from 1.19 to 1.31 for the SCZ‐PRS, and from 1.07 to 1.29 for the BPD‐PRS. Furthermore, we show that as regular smoking becomes more stigmatized and less prevalent, these biological risk factors gain importance as determinants of the behavior.

KW - Polygenic scores

KW - Psychotic disorders

KW - Substance abuse

KW - Fíkn

KW - Tóbaksnotkun

KW - Áfengissýki

KW - Fíkniefnaneysla

KW - Geðklofi

KW - Geðhvarfasýki

KW - Geðsjúkdómar

KW - Gen

KW - PSY12

KW - Multifactorial Inheritance

KW - Mental Disorders

KW - Substance-Related Disorders

KW - Polygenic scores

KW - Psychotic disorders

KW - Substance abuse

KW - Fíkn

KW - Tóbaksnotkun

KW - Áfengissýki

KW - Fíkniefnaneysla

KW - Geðklofi

KW - Geðhvarfasýki

KW - Geðsjúkdómar

KW - Gen

KW - PSY12

KW - Multifactorial Inheritance

KW - Mental Disorders

KW - Substance-Related Disorders

U2 - 10.1111/adb.12496

DO - 10.1111/adb.12496

M3 - Article

SN - 1355-6215

VL - 23

SP - 485

EP - 492

JO - Addiction Biology

JF - Addiction Biology

IS - 1

ER -

Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction

Abstract

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