Physical and neurobehavioral determinants of reproductive onset and success

Felix R. Day; Hannes Helgason; Daniel I. Chasman; Lynda M. Rose; Po Ru Loh; Robert A. Scott; Agnar Helgason; Augustine Kong; Gisli Masson; Olafur Th Magnusson; Daniel Gudbjartsson; Unnur Thorsteinsdottir; Julie E. Buring; Paul M. Ridker; Patrick Sulem; Kari Stefansson; Ken K. Ong; John R.B. Perry

doi:10.1038/ng.3551

Physical and neurobehavioral determinants of reproductive onset and success

Felix R. Day, Hannes Helgason, Daniel I. Chasman, Lynda M. Rose, Po Ru Loh, Robert A. Scott, Agnar Helgason, Augustine Kong, Gisli Masson, Olafur Th Magnusson, Daniel Gudbjartsson, Unnur Thorsteinsdottir, Julie E. Buring, Paul M. Ridker, Patrick Sulem, Kari Stefansson, Ken K. Ong^*, John R.B. Perry

^*Corresponding author for this work

Faculty of Sociology, Anthropology and Folkloristics

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

The ages of puberty, first sexual intercourse and first birth signify the onset of reproductive ability, behavior and success, respectively. In a genome-wide association study of 125,667 UK Biobank participants, we identify 38 loci associated (P < 5 × 10 -8) with age at first sexual intercourse. These findings were taken forward in 241,910 men and women from Iceland and 20,187 women from the Women's Genome Health Study. Several of the identified loci also exhibit associations (P < 5 × 10 -8) with other reproductive and behavioral traits, including age at first birth (variants in or near ESR1 and RBM6-SEMA3F), number of children (CADM2 and ESR1), irritable temperament (MSRA) and risk-taking propensity (CADM2). Mendelian randomization analyses infer causal influences of earlier puberty timing on earlier first sexual intercourse, earlier first birth and lower educational attainment. In turn, likely causal consequences of earlier first sexual intercourse include reproductive, educational, psychiatric and cardiometabolic outcomes.

Original language	English
Pages (from-to)	617-623
Number of pages	7
Journal	Nature Genetics
Volume	48
Issue number	6
DOIs	https://doi.org/10.1038/ng.3551
Publication status	Published - 1 Jun 2016

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© 2016 Nature America, Inc.

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Day, F. R., Helgason, H., Chasman, D. I., Rose, L. M., Loh, P. R., Scott, R. A., Helgason, A., Kong, A., Masson, G., Magnusson, O. T., Gudbjartsson, D., Thorsteinsdottir, U., Buring, J. E., Ridker, P. M., Sulem, P., Stefansson, K., Ong, K. K., & Perry, J. R. B. (2016). Physical and neurobehavioral determinants of reproductive onset and success. Nature Genetics, 48(6), 617-623. https://doi.org/10.1038/ng.3551

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title = "Physical and neurobehavioral determinants of reproductive onset and success",

abstract = "The ages of puberty, first sexual intercourse and first birth signify the onset of reproductive ability, behavior and success, respectively. In a genome-wide association study of 125,667 UK Biobank participants, we identify 38 loci associated (P < 5 × 10 -8) with age at first sexual intercourse. These findings were taken forward in 241,910 men and women from Iceland and 20,187 women from the Women's Genome Health Study. Several of the identified loci also exhibit associations (P < 5 × 10 -8) with other reproductive and behavioral traits, including age at first birth (variants in or near ESR1 and RBM6-SEMA3F), number of children (CADM2 and ESR1), irritable temperament (MSRA) and risk-taking propensity (CADM2). Mendelian randomization analyses infer causal influences of earlier puberty timing on earlier first sexual intercourse, earlier first birth and lower educational attainment. In turn, likely causal consequences of earlier first sexual intercourse include reproductive, educational, psychiatric and cardiometabolic outcomes.",

author = "Day, {Felix R.} and Hannes Helgason and Chasman, {Daniel I.} and Rose, {Lynda M.} and Loh, {Po Ru} and Scott, {Robert A.} and Agnar Helgason and Augustine Kong and Gisli Masson and Magnusson, {Olafur Th} and Daniel Gudbjartsson and Unnur Thorsteinsdottir and Buring, {Julie E.} and Ridker, {Paul M.} and Patrick Sulem and Kari Stefansson and Ong, {Ken K.} and Perry, {John R.B.}",

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Day, FR, Helgason, H, Chasman, DI, Rose, LM, Loh, PR, Scott, RA, Helgason, A, Kong, A, Masson, G, Magnusson, OT, Gudbjartsson, D, Thorsteinsdottir, U, Buring, JE, Ridker, PM, Sulem, P, Stefansson, K, Ong, KK & Perry, JRB 2016, 'Physical and neurobehavioral determinants of reproductive onset and success', Nature Genetics, vol. 48, no. 6, pp. 617-623. https://doi.org/10.1038/ng.3551

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Physical and neurobehavioral determinants of reproductive onset and success

Abstract

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