Abstract
Large system peaks may occur when a sample is introduced into a liquid chromatographic system if the composition of the solute deviates considerably from that of the mobile phase. The composition of the mobile phase in a system peak is different from the bulk of the mobile phase, and analytes that are eluted in such a zone, or have been eluted together with the zone during the separation, may be detected as compressed or deformed peaks. The development of compressed peaks will improve the detection limits, although the appearance of deformed peaks makes the system unsuitable for quantitative analysis. In Part I of this article, the background to this phenomenon is given as well as guidelines on how to obtain compressed peaks. Possible future research directions are also discussed.
| Original language | English |
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| Pages (from-to) | 747-760 |
| Number of pages | 14 |
| Journal | LC GC Europe |
| Volume | 9 |
| Issue number | 11 |
| Publication status | Published - Nov 1996 |