TY - JOUR
T1 - p-Chloroamphetamine-induced rat ejaculation is not associated with the preoptic nucleus or medial nucleus amygdala
AU - Yokosuka, Makoto
AU - Takagi, Shunsuke
AU - Katou, Masahiro
AU - Pudcharaporn, Kromkhum
AU - Gizurarson, Sveinbjorn
AU - Ichikawa, Masumi
AU - Saito, Toru R.
PY - 2008/3
Y1 - 2008/3
N2 - Aim: In the rat, intraperitoneal injection of p -chloroamphetamine (PCA), which releases central 5-hydroxytryptamine (5-HT) from serotonergic nerve terminals, induces ejaculation, even in the absence of an estrus female or female-related smell information. It is well known that the medial preoptic nucleus (MPN) and the medial nucleus amygdala (MEA) play a major role in the control of male sexual behavior in mammals. We examined whether or not neuronal activity of the MPN and/or the MEA was associated with PCA-induced ejaculation. Methods: Using c-Fos immunohistochemistry, we demonstrated a difference in the neural activities of the MPN and the MEA for ejaculation during copulation with an estrus female and ejaculation by PCA injection. Results: Increased numbers of c-Fos-immunoreactive (c-Fos-IR) cells were found in the MPN and the MEA in the brains of the mating animals, whereas in the brains of the animals undergoing PCA-induced ejaculation there was no increase in the number of c-Fos-IR cells in the MPN and a small increase in the MEA. Conclusion: Based on these results, ejaculation induced by PCA is not associated with the MPN. Moreover, the MEA is not the main act for this ejaculation. Journal compilation
AB - Aim: In the rat, intraperitoneal injection of p -chloroamphetamine (PCA), which releases central 5-hydroxytryptamine (5-HT) from serotonergic nerve terminals, induces ejaculation, even in the absence of an estrus female or female-related smell information. It is well known that the medial preoptic nucleus (MPN) and the medial nucleus amygdala (MEA) play a major role in the control of male sexual behavior in mammals. We examined whether or not neuronal activity of the MPN and/or the MEA was associated with PCA-induced ejaculation. Methods: Using c-Fos immunohistochemistry, we demonstrated a difference in the neural activities of the MPN and the MEA for ejaculation during copulation with an estrus female and ejaculation by PCA injection. Results: Increased numbers of c-Fos-immunoreactive (c-Fos-IR) cells were found in the MPN and the MEA in the brains of the mating animals, whereas in the brains of the animals undergoing PCA-induced ejaculation there was no increase in the number of c-Fos-IR cells in the MPN and a small increase in the MEA. Conclusion: Based on these results, ejaculation induced by PCA is not associated with the MPN. Moreover, the MEA is not the main act for this ejaculation. Journal compilation
KW - c-Fos
KW - Ejaculation
KW - Medial nucleus amygdala
KW - Medial preoptic nucleus
KW - ρ-chloroamphetamine
UR - http://www.scopus.com/inward/record.url?scp=38949156778&partnerID=8YFLogxK
U2 - 10.1111/j.1447-0578.2007.00199.x
DO - 10.1111/j.1447-0578.2007.00199.x
M3 - Article
AN - SCOPUS:38949156778
SN - 1445-5781
VL - 7
SP - 37
EP - 43
JO - Reproductive Medicine and Biology
JF - Reproductive Medicine and Biology
IS - 1
ER -