Obesity in adolescents does not influence early immune responses to influenza vaccination

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Obesity has been linked to reduced vaccine responses against tetanus, hepatitis B and influenza. Data on the influence of paediatric obesity on influenza vaccine response is still lacking and this study aims to fill the gap.

METHODS: A total of 30 children with obesity and 30 children with normal weight, aged 12-18 years, were recruited. Participants were vaccinated with a tetravalent influenza vaccine. Blood was collected prior to the vaccination and again four weeks later. The humoral response was assessed with haemagglutinin inhibition assay. The cellular response was assessed with T-cell stimulation assays measuring TNF-α, IFN-γ, IL-2 and IL-13.

RESULTS: Of the 29/30 from the study group and 30/30 from the control group finished both visits. Seroconversion occurred for > 90% of participants in both groups for the A/H1N1, A/H3N2 and B/Victoria strains, but the B/Yamagata strain had lower seroconversion rates (93% in the study group and 80% in the control group). 97-100% of participants from both groups had adequate serological responses following vaccination. Cellular responses were similar between the two groups post-vaccination.

CONCLUSIONS: Early humoral and cellular immune responses to influenza vaccinations are similar among adolescents with obesity and normal weight.

Original languageEnglish
Pages (from-to)415-424
Number of pages10
JournalInfectious diseases (London, England)
Volume55
Issue number6
DOIs
Publication statusPublished - Jun 2023

Bibliographical note

Publisher Copyright:
© 2023 Society for Scandinavian Journal of Infectious Diseases.

Publisher Copyright:
© 2023 Society for Scandinavian Journal of Infectious Diseases.

Funding Information:
This study was supported by The Icelandic Centre for Research [grant number 206629-051] and Landspitali Research Fund [grant number A-2019-087]. We thank all the participants for their contribution to the study. 66°North is acknowledged for providing gift certificates for outdoor clothing as a reward for participants.

Publisher Copyright:
© 2023 Society for Scandinavian Journal of Infectious Diseases.

Other keywords

  • adolescents
  • Immune response
  • influenza
  • influenza vaccinations
  • obesity

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