NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia.

Morten Tulstrup; Marie Grosjean; Stine Nygaard Nielsen; Kathrine Grell; Benjamin Ole Wolthers; Peder Skov Wegener; Olafur Gisli Jonsson; Bendik Lund; Arja Harila-Saari; Jonas Abrahamsson; Goda Vaitkeviciene; Kaie Pruunsild; Nina Toft; Mette Holm; Erik Hulegårdh; Sigurd Liestøl; Laimonas Griskevicius; Mari Punab; Jinhua Wang; William L Carroll; Zeyu Zhang; Marlene D Dalgaard; Ramneek Gupta; Jacob Nersting; Kjeld Schmiegelow

doi:10.1038/s41375-018-0245-3

NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia.

Morten Tulstrup, Marie Grosjean, Stine Nygaard Nielsen, Kathrine Grell, Benjamin Ole Wolthers, Peder Skov Wegener, Olafur Gisli Jonsson, Bendik Lund, Arja Harila-Saari, Jonas Abrahamsson, Goda Vaitkeviciene, Kaie Pruunsild, Nina Toft, Mette Holm, Erik Hulegårdh, Sigurd Liestøl, Laimonas Griskevicius, Mari Punab, Jinhua Wang, William L CarrollZeyu Zhang, Marlene D Dalgaard, Ramneek Gupta, Jacob Nersting, Kjeld Schmiegelow

Landspitali - The National University Hospital of Iceland

Research output: Contribution to journal › Article › peer-review

Abstract

The antileukaemic drug 6-mercaptopurine is converted into thioguanine nucleotides (TGN) and incorporated into DNA (DNA-TG), the active end metabolite. In a series of genome-wide association studies, we analysed time-weighted means (

Original language	English
Journal	Leukemia
DOIs	https://doi.org/10.1038/s41375-018-0245-3
Publication status	Published - 1 Dec 2018

Other keywords

Bráðahvítblæði
Börn
Lyfjameðferð
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Drug Therapy

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10.1038/s41375-018-0245-3

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Tulstrup, M., Grosjean, M., Nielsen, S. N., Grell, K., Wolthers, B. O., Wegener, P. S., Jonsson, O. G., Lund, B., Harila-Saari, A., Abrahamsson, J., Vaitkeviciene, G., Pruunsild, K., Toft, N., Holm, M., Hulegårdh, E., Liestøl, S., Griskevicius, L., Punab, M., Wang, J., ... Schmiegelow, K. (2018). NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia. Leukemia. https://doi.org/10.1038/s41375-018-0245-3

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title = "NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia.",

abstract = "The antileukaemic drug 6-mercaptopurine is converted into thioguanine nucleotides (TGN) and incorporated into DNA (DNA-TG), the active end metabolite. In a series of genome-wide association studies, we analysed time-weighted means (",

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author = "Morten Tulstrup and Marie Grosjean and Nielsen, {Stine Nygaard} and Kathrine Grell and Wolthers, {Benjamin Ole} and Wegener, {Peder Skov} and Jonsson, {Olafur Gisli} and Bendik Lund and Arja Harila-Saari and Jonas Abrahamsson and Goda Vaitkeviciene and Kaie Pruunsild and Nina Toft and Mette Holm and Erik Huleg{\aa}rdh and Sigurd Liest{\o}l and Laimonas Griskevicius and Mari Punab and Jinhua Wang and Carroll, {William L} and Zeyu Zhang and Dalgaard, {Marlene D} and Ramneek Gupta and Jacob Nersting and Kjeld Schmiegelow",

year = "2018",

month = dec,

day = "1",

doi = "10.1038/s41375-018-0245-3",

language = "English",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Nature Publishing Group",

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Tulstrup, M, Grosjean, M, Nielsen, SN, Grell, K, Wolthers, BO, Wegener, PS, Jonsson, OG, Lund, B, Harila-Saari, A, Abrahamsson, J, Vaitkeviciene, G, Pruunsild, K, Toft, N, Holm, M, Hulegårdh, E, Liestøl, S, Griskevicius, L, Punab, M, Wang, J, Carroll, WL, Zhang, Z, Dalgaard, MD, Gupta, R, Nersting, J & Schmiegelow, K 2018, 'NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia.', Leukemia. https://doi.org/10.1038/s41375-018-0245-3

TY - JOUR

T1 - NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia.

AU - Tulstrup, Morten

AU - Grosjean, Marie

AU - Nielsen, Stine Nygaard

AU - Grell, Kathrine

AU - Wolthers, Benjamin Ole

AU - Wegener, Peder Skov

AU - Jonsson, Olafur Gisli

AU - Lund, Bendik

AU - Harila-Saari, Arja

AU - Abrahamsson, Jonas

AU - Vaitkeviciene, Goda

AU - Pruunsild, Kaie

AU - Toft, Nina

AU - Holm, Mette

AU - Hulegårdh, Erik

AU - Liestøl, Sigurd

AU - Griskevicius, Laimonas

AU - Punab, Mari

AU - Wang, Jinhua

AU - Carroll, William L

AU - Zhang, Zeyu

AU - Dalgaard, Marlene D

AU - Gupta, Ramneek

AU - Nersting, Jacob

AU - Schmiegelow, Kjeld

PY - 2018/12/1

Y1 - 2018/12/1

N2 - The antileukaemic drug 6-mercaptopurine is converted into thioguanine nucleotides (TGN) and incorporated into DNA (DNA-TG), the active end metabolite. In a series of genome-wide association studies, we analysed time-weighted means (

AB - The antileukaemic drug 6-mercaptopurine is converted into thioguanine nucleotides (TGN) and incorporated into DNA (DNA-TG), the active end metabolite. In a series of genome-wide association studies, we analysed time-weighted means (

KW - Bráðahvítblæði

KW - Börn

KW - Lyfjameðferð

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma

KW - Drug Therapy

KW - Bráðahvítblæði

KW - Börn

KW - Lyfjameðferð

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma

KW - Drug Therapy

U2 - 10.1038/s41375-018-0245-3

DO - 10.1038/s41375-018-0245-3

M3 - Article

C2 - 30201983

SN - 0887-6924

JO - Leukemia

JF - Leukemia

ER -

NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia.

Abstract

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