New sequence variants associated with bone mineral density

Unnur Styrkarsdottir; Bjarni V. Halldorsson; Solveig Gretarsdottir; Daniel F. Gudbjartsson; G. Bragi Walters; Thorvaldur Ingvarsson; Thorbjorg Jonsdottir; Jona Saemundsdottir; Steinunn Snorradóttir; Jacqueline R. Center; Tuan V. Nguyen; Peter Alexandersen; Jeffrey R. Gulcher; John A. Eisman; Claus Christiansen; Gunnar Sigurdsson; Augustine Kong; Unnur Thorsteinsdottir; Kari Stefansson

doi:10.1038/ng.284

New sequence variants associated with bone mineral density

Unnur Styrkarsdottir^*, Bjarni V. Halldorsson, Solveig Gretarsdottir, Daniel F. Gudbjartsson, G. Bragi Walters, Thorvaldur Ingvarsson, Thorbjorg Jonsdottir, Jona Saemundsdottir, Steinunn Snorradóttir, Jacqueline R. Center, Tuan V. Nguyen, Peter Alexandersen, Jeffrey R. Gulcher, John A. Eisman, Claus Christiansen, Gunnar Sigurdsson, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

266 Citations (Scopus)

Abstract

In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density.

Original language	English
Pages (from-to)	15-17
Number of pages	3
Journal	Nature Genetics
Volume	41
Issue number	1
DOIs	https://doi.org/10.1038/ng.284
Publication status	Published - Jan 2009

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Styrkarsdottir, U., Halldorsson, B. V., Gretarsdottir, S., Gudbjartsson, D. F., Walters, G. B., Ingvarsson, T., Jonsdottir, T., Saemundsdottir, J., Snorradóttir, S., Center, J. R., Nguyen, T. V., Alexandersen, P., Gulcher, J. R., Eisman, J. A., Christiansen, C., Sigurdsson, G., Kong, A., Thorsteinsdottir, U., & Stefansson, K. (2009). New sequence variants associated with bone mineral density. Nature Genetics, 41(1), 15-17. https://doi.org/10.1038/ng.284

@article{14663188dbdd4bdba408b62fc964b1ef,

title = "New sequence variants associated with bone mineral density",

abstract = "In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density.",

author = "Unnur Styrkarsdottir and Halldorsson, {Bjarni V.} and Solveig Gretarsdottir and Gudbjartsson, {Daniel F.} and Walters, {G. Bragi} and Thorvaldur Ingvarsson and Thorbjorg Jonsdottir and Jona Saemundsdottir and Steinunn Snorrad{\'o}ttir and Center, {Jacqueline R.} and Nguyen, {Tuan V.} and Peter Alexandersen and Gulcher, {Jeffrey R.} and Eisman, {John A.} and Claus Christiansen and Gunnar Sigurdsson and Augustine Kong and Unnur Thorsteinsdottir and Kari Stefansson",

year = "2009",

month = jan,

doi = "10.1038/ng.284",

language = "English",

volume = "41",

pages = "15--17",

journal = "Nature Genetics",

issn = "1061-4036",

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Styrkarsdottir, U, Halldorsson, BV, Gretarsdottir, S, Gudbjartsson, DF, Walters, GB, Ingvarsson, T, Jonsdottir, T, Saemundsdottir, J, Snorradóttir, S, Center, JR, Nguyen, TV, Alexandersen, P, Gulcher, JR, Eisman, JA, Christiansen, C, Sigurdsson, G, Kong, A, Thorsteinsdottir, U & Stefansson, K 2009, 'New sequence variants associated with bone mineral density', Nature Genetics, vol. 41, no. 1, pp. 15-17. https://doi.org/10.1038/ng.284

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T1 - New sequence variants associated with bone mineral density

AU - Styrkarsdottir, Unnur

AU - Halldorsson, Bjarni V.

AU - Gretarsdottir, Solveig

AU - Gudbjartsson, Daniel F.

AU - Walters, G. Bragi

AU - Ingvarsson, Thorvaldur

AU - Jonsdottir, Thorbjorg

AU - Saemundsdottir, Jona

AU - Snorradóttir, Steinunn

AU - Center, Jacqueline R.

AU - Nguyen, Tuan V.

AU - Alexandersen, Peter

AU - Gulcher, Jeffrey R.

AU - Eisman, John A.

AU - Christiansen, Claus

AU - Sigurdsson, Gunnar

AU - Kong, Augustine

AU - Thorsteinsdottir, Unnur

AU - Stefansson, Kari

PY - 2009/1

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AB - In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density.

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DO - 10.1038/ng.284

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SN - 1061-4036

VL - 41

SP - 15

EP - 17

JO - Nature Genetics

JF - Nature Genetics

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ER -

New sequence variants associated with bone mineral density

Abstract

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