New Fluvirucinins C1 and C2 Produced by a Marine Derived Actinomycete

Margarida Costa; Paz Zúñiga; Ana Ma Peñalver; Margrét Thorsteinsdottir; Marta Pérez; Librada M. Cañedo; Carmen Cuevas

doi:10.1177/1934578x1701200509

New Fluvirucinins C₁ and C₂ Produced by a Marine Derived Actinomycete

Margarida Costa, Paz Zúñiga, Ana Ma Peñalver, Margrét Thorsteinsdottir, Marta Pérez, Librada M. Cañedo^*, Carmen Cuevas

^*Corresponding author for this work

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Two new fluvirucin aglycones, named fluvirucinins C₁ and C₂ (1-2), have been isolated from the ethyl acetate mycelial cake extract of the fermentation broth of a marine sponge-associated actinomycete. Fluvirucinins C₁ (1) and C₂ (2) represent a new type of 14-membered macrolactam aglycon, structurally related with the common aglycon of the known fluvirucins. Their structures were elucidated on the basis of 1D and 2D NMR analyses, as well as HRESIMS experiments. The antimicrobial and cytotoxic activities of compounds 1 and 2 have been evaluated, but no significant activities found for fluvirucinins C₁ and C₂.

Original language	English
Pages (from-to)	679-682
Number of pages	4
Journal	Natural Product Communications
Volume	12
Issue number	5
DOIs	https://doi.org/10.1177/1934578x1701200509
Publication status	Published - May 2017

Other keywords

14-Membered macrolactam aglycon
Fluvirucin aglycones
Fluvirucinin derivatives
Marine sponge-associated actinomycete

Access to Document

10.1177/1934578x1701200509

Cite this

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title = "New Fluvirucinins C1 and C2 Produced by a Marine Derived Actinomycete",

abstract = "Two new fluvirucin aglycones, named fluvirucinins C1 and C2 (1-2), have been isolated from the ethyl acetate mycelial cake extract of the fermentation broth of a marine sponge-associated actinomycete. Fluvirucinins C1 (1) and C2 (2) represent a new type of 14-membered macrolactam aglycon, structurally related with the common aglycon of the known fluvirucins. Their structures were elucidated on the basis of 1D and 2D NMR analyses, as well as HRESIMS experiments. The antimicrobial and cytotoxic activities of compounds 1 and 2 have been evaluated, but no significant activities found for fluvirucinins C1 and C2.",

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author = "Margarida Costa and Paz Z{\'u}{\~n}iga and Pe{\~n}alver, {Ana Ma} and Margr{\'e}t Thorsteinsdottir and Marta P{\'e}rez and Ca{\~n}edo, {Librada M.} and Carmen Cuevas",

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T1 - New Fluvirucinins C1 and C2 Produced by a Marine Derived Actinomycete

AU - Costa, Margarida

AU - Zúñiga, Paz

AU - Peñalver, Ana Ma

AU - Thorsteinsdottir, Margrét

AU - Pérez, Marta

AU - Cañedo, Librada M.

AU - Cuevas, Carmen

PY - 2017/5

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N2 - Two new fluvirucin aglycones, named fluvirucinins C1 and C2 (1-2), have been isolated from the ethyl acetate mycelial cake extract of the fermentation broth of a marine sponge-associated actinomycete. Fluvirucinins C1 (1) and C2 (2) represent a new type of 14-membered macrolactam aglycon, structurally related with the common aglycon of the known fluvirucins. Their structures were elucidated on the basis of 1D and 2D NMR analyses, as well as HRESIMS experiments. The antimicrobial and cytotoxic activities of compounds 1 and 2 have been evaluated, but no significant activities found for fluvirucinins C1 and C2.

AB - Two new fluvirucin aglycones, named fluvirucinins C1 and C2 (1-2), have been isolated from the ethyl acetate mycelial cake extract of the fermentation broth of a marine sponge-associated actinomycete. Fluvirucinins C1 (1) and C2 (2) represent a new type of 14-membered macrolactam aglycon, structurally related with the common aglycon of the known fluvirucins. Their structures were elucidated on the basis of 1D and 2D NMR analyses, as well as HRESIMS experiments. The antimicrobial and cytotoxic activities of compounds 1 and 2 have been evaluated, but no significant activities found for fluvirucinins C1 and C2.

KW - 14-Membered macrolactam aglycon

KW - Fluvirucin aglycones

KW - Fluvirucinin derivatives

KW - Marine sponge-associated actinomycete

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