New Fluvirucinins C1 and C2 Produced by a Marine Derived Actinomycete

Margarida Costa, Paz Zúñiga, Ana Ma Peñalver, Margrét Thorsteinsdottir, Marta Pérez, Librada M. Cañedo*, Carmen Cuevas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Two new fluvirucin aglycones, named fluvirucinins C1 and C2 (1-2), have been isolated from the ethyl acetate mycelial cake extract of the fermentation broth of a marine sponge-associated actinomycete. Fluvirucinins C1 (1) and C2 (2) represent a new type of 14-membered macrolactam aglycon, structurally related with the common aglycon of the known fluvirucins. Their structures were elucidated on the basis of 1D and 2D NMR analyses, as well as HRESIMS experiments. The antimicrobial and cytotoxic activities of compounds 1 and 2 have been evaluated, but no significant activities found for fluvirucinins C1 and C2.

Original languageEnglish
Pages (from-to)679-682
Number of pages4
JournalNatural Product Communications
Issue number5
Publication statusPublished - May 2017

Other keywords

  • 14-Membered macrolactam aglycon
  • Fluvirucin aglycones
  • Fluvirucinin derivatives
  • Marine sponge-associated actinomycete


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