Neuroglial interactions underpinning myelin plasticity

Omar de Faria, Ewa Anastazia Claudia Pama, Kimberley Evans, Aryna Luzhynskaya, Ragnhildur Thóra Káradóttir*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)


The CNS is extremely responsive to an ever-changing environment. Studies of neural circuit plasticity focus almost exclusively on functional and structural changes of neuronal synapses. In recent years, however, myelin plasticity has emerged as a potential modulator of neuronal networks. Myelination of previously unmyelinated axons and changes in the structure of myelin on already-myelinated axons (similar to changes in internode number and length or myelin thickness or geometry of the nodal area) can in theory have significant effects on the function of neuronal networks. In this article, the authors review the current evidence for myelin changes occurring in the adult CNS, highlight some potential underlying mechanisms of how neuronal activity may regulate myelin changes, and explore the similarities between neuronal and myelin plasticity.

Original languageEnglish
Pages (from-to)93-107
Number of pages15
JournalDevelopmental Neurobiology
Issue number2
Publication statusPublished - Feb 2018

Bibliographical note

Publisher Copyright:
© 2017 Wiley Periodicals, Inc.

Other keywords

  • myelin
  • myelination
  • neuronal activity
  • neurotransmitters
  • oligodendrocyte


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