Neuroblastoma incidence and survival in European children (1978-1997): Report from the Automated Childhood Cancer Information System project

Claudia Spix*, Guido Pastore, Risto Sankila, Charles A. Stiller, Eva Steliarova-Foucher, S. V. Petrovich, O. Budanov, H. Storm, N. Christensen, T. Aareleid, T. Hakulinen, E. Pukkala, E. Le Gall, I. Tron, B. Lacour, E. Desandes, J. L. Bernard, P. Pillon, J. C. Gentet, F. FreyconC. Berger, L. Remontet, A. Danzon, M. Mercier, J. P. Daurè s, B. Tretarre, F. Ménégoz, A. V. Guizard, M. Velten, A. Buemi, N. Raverdy, M. Sauvage, P. Grosclaude, P. Kaatsch, B. Eisinger, R. Stabenow, D. Schuler, Z. Jakab, G. Borgulya, L. Tryggvadottir, J. G. Jonasson, K. Bjarnadottir, H. Comber, F. Dwane, C. Magnani, F. Pannelli, C. Pascucci, S. Ferretti, E. Conti, V. Ramazzotti, M. C. Cercato, M. Vercelli, A. Puppo, P. Crosignani, G. Tagliabue, A. Tittarelli, V. De Lisi, P. Sgargi, R. Tumino, M. Budroni, D. Piras, E. Paci, E. Crocetti, F. La Rosa, F. Stracci, P. Zambon, S. Guzzinati, M. Dalmas, J. W.W. Coebergh, J. van Dijck, A. Wit, F. Langmark, A. Johansen, A. Andersen, I. Plesko, M. Primic Z? akelj, V. Pompe-Kirn, R. Peris-Bonet, B. Giner, E. Almar Marques, A. Mateos Ramos, J. Ramon Quiros Garcia, A. Can˜ ada Martínez, I. Izarzugaza, A. Alemán Herrera, P. Viladiu, R. Marcos, A. Izquierdo, C. Martínez Garcia, A. Obrador, I. Garau, E. Ardanaz, J. Borrà s, J. Galceran, J. de la Bá rcena Guallar, M. C. Martos Jiménez, G. Jundt, C. Bouchardy, M. Usel, J. Allemann, H. Frick, T. Fisch, S. Ess, F. Joris, D. de Weck, S. Yalcin Eser, M. F.G. Murphy, G. J. Draper, A. Gavin, C. Fox, W. Hamill, R. Middleton, D. Brewster, L. Bhatti, A. McDonald

*Corresponding author for this work

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The Automated Childhood Cancer Information System (ACCIS) collects and presents data on childhood cancer in Europe. This report describes trends (1978-1997) and geographical differences (1988-1997) in incidence and survival for 6202 children with neuroblastoma from 59 registries in 19 countries, grouped into five regions (British Isles, West, East, North, and South). The age-standardised incidence rate (ASR) of neuroblastoma in Europe in 1988-1997 was 10.9 cases per million children, being highest in infants (52.6). The ASR of neuroblastoma increased in Europe from 8.4 in 1978-1982 to 11.6 in 1993-1997, mostly due to an increase in infants (from 35.4 to 57.8). Overall 5-year survival was 59%, ranging from 47% (East) to 67% (West). It improved markedly from 37% in 1978-1982 to 66% in 1993-1997, especially in infants. A certain amount of overdiagnosis in children under 2 years of age may explain the increased incidence rates and partially the increase in survival. Survival of older children (aged 2-14 years), which is likely to be largely affected by therapy, has also improved from 21% to 45%.

Original languageEnglish
Pages (from-to)2081-2091
Number of pages11
JournalEuropean Journal of Cancer
Issue number13
Publication statusPublished - 1 Sept 2006

Bibliographical note

Funding Information:
The ACCIS project was funded by the European Commission from ’Europe Against Cancer’ action programme (1996–2002) (contracts SI2.126875, SI2.321970 and SPC.2002303), jointly with International Agency for Research on Cancer (IARC). Data analyses were partly financed by the French Ligue National Contre le Cancer, Comité du Rhône . The Childhood Cancer Research Group receives funding from the Department of Health and the Scottish Ministers. The views expressed in the publication are those of the authors and not necessarily those of the Department of Health and the Scottish Ministers.

Other keywords

  • Childhood cancer
  • Europe
  • Incidence
  • Neuroblastoma
  • Registry
  • Survival
  • Trend


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