Mucosal vaccination with an attenuated maedi-visna virus clone

Gudmundur Pétursson*, Sigrídur Matthíasdóttir, Vilhjálmur Svansson, Valgerdur Andrésdóttir, Gudmundur Georgsson, Agnes H. Martin, Gudrún Agnarsdóttir, Eygló Gísladóttir, Steinunn Árnadóttir, Svava Högnadóttir, Stefán Ragnar Jónsson, Ólafur S. Andrésson, Sigurbjörg Torsteinsdóttir

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Four sheep were infected intratracheally with an attenuated molecular clone of maedi-visna virus (MVV). All four became infected. Ten months later these sheep were challenged intratracheally with a genetically similar but pathogenic clone of MVV. Four unvaccinated sheep were infected simultaneously. All sheep became infected by the challenge virus. The vaccinated sheep were not protected against superinfection with the challenge clone. However, virus was isolated more frequently from the blood of the unvaccinated controls than of the vaccinated animals and ten times more frequently from lungs of unvaccinated sheep than from lungs of vaccinated sheep at sacrifice, indicating partial protection.

Original languageEnglish
Pages (from-to)3223-3228
Number of pages6
JournalVaccine
Volume23
Issue number24
DOIs
Publication statusPublished - 2 May 2005

Bibliographical note

Funding Information:
The authors thank Gudbjörg Ólafsdóttir for expert assistance in preparation of illustrations. This research was supported by a grant from the Icelandic Research Foundation.

Other keywords

  • Attenuated virus
  • Maedi-visna
  • Mucosal vaccination

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