Abstract
Background: Relatively few studies have examined survival by pharmacotherapy level and the effects of patient characteristics on mortality by pharmacotherapy level in older chronic respiratory disease (CRD) patients. This study aimed to investigate these issues in older (≥ 65) CRD patients in Western Australia. Methods: We identified 108,312 patients ≥ 65 years with CRD during 1992-2006 using linked medical, pharmaceutical, hospital and mortality databases held by the Commonwealth and State governments. Pharmacotherapy classification levels were designed by a clinical consensus panel. Cox regression was used to investigate the study aim. Results: Patients using only short acting bronchodilators experienced similar, but slightly worse survival than patients in the highest pharmacotherapy level group using high dose inhaled corticosteroids (ICS) ± long acting bronchodilators (LABs) ± oral steroids. Patients using low to medium dose ICS ± LABs experienced relatively better survival. Also, male gender was associated with all-cause mortality in all patients (HR = 1.72, 95% CI 1.65-1.80) and especially in those in the highest pharmacotherapy level group (HR = 1.97, 95%CI = 1.84-2.10). The P-value of interaction between gender and pharmacotherapy level for the effect on all-cause death was significant (0.0003). Conclusions: Older patients with CRD not using ICS experienced the worst survival in this study and may benefit from an escalation in therapeutic regime. Males had a higher risk of death than females, which was more pronounced in the highest pharmacotherapy level group. Hence, primary health care should more actively direct disease management to mild-to-moderate disease patients.
| Original language | English |
|---|---|
| Article number | 385 |
| Journal | BMC Public Health |
| Volume | 10 |
| DOIs | |
| Publication status | Published - 2010 |
Bibliographical note
Funding Information:We wish to thank the Australian Department of Health and Ageing, Medicare Australia and the Australian Electoral Commission as well as the WA Department of Health and the Registrar Generals Office of WA for providing the data used for this investigation. We are furthermore grateful to the Data Linkage Branch of the WA Department of Health for extracting and linking the data. We also thank the clinical consensus panel who developed guidelines for the CRD pharmacotherapy levels: Dr Christopher Beer; Dr Nick Bretland; Ms Helen Brown; Ms Amanda Bryce; Prof David Bruce; Dr Maureen Cazalet; Mr Mark Coles; Dr Ted Collinson; Dr Nick Cooke; Dr Peter Foley; Dr Khoo; and Dr Patrick Mulhern. The research was supported by a project grant from Australia's National Health and Medical Research Council.