Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease

Sang Bing Ong; Siavash Beikoghli Kalkhoran; Hector A. Cabrera-Fuentes; Derek J. Hausenloy

doi:10.1016/j.ejphar.2015.04.056

Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease

Sang Bing Ong, Siavash Beikoghli Kalkhoran, Hector A. Cabrera-Fuentes, Derek J. Hausenloy^*

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

80 Citations (Scopus)

Abstract

The past decade has witnessed a number of exciting developments in the field of mitochondrial dynamics - a phenomenon in which changes in mitochondrial shape and movement impact on cellular physiology and pathology. By undergoing fusion and fission, mitochondria are able to change their morphology between elongated interconnected networks and discrete fragmented structures, respectively. The cardiac mitochondria, in particular, have garnered much interest due to their unique spatial arrangement in the adult cardiomyocyte, and the multiple roles they play in cell death and survival. In this article, we review the role of the mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease.

Original language	English
Pages (from-to)	104-114
Number of pages	11
Journal	European Journal of Pharmacology
Volume	763
DOIs	https://doi.org/10.1016/j.ejphar.2015.04.056
Publication status	Published - 15 Sept 2015

Bibliographical note

Publisher Copyright:
© 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license.

Other keywords

Drp1
MFN1
MFN2
Mitochondrial fission
Mitochondrial fusion
OPA1

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title = "Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease",

abstract = "The past decade has witnessed a number of exciting developments in the field of mitochondrial dynamics - a phenomenon in which changes in mitochondrial shape and movement impact on cellular physiology and pathology. By undergoing fusion and fission, mitochondria are able to change their morphology between elongated interconnected networks and discrete fragmented structures, respectively. The cardiac mitochondria, in particular, have garnered much interest due to their unique spatial arrangement in the adult cardiomyocyte, and the multiple roles they play in cell death and survival. In this article, we review the role of the mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease.",

keywords = "Drp1, MFN1, MFN2, Mitochondrial fission, Mitochondrial fusion, OPA1",

author = "Ong, {Sang Bing} and Kalkhoran, {Siavash Beikoghli} and Cabrera-Fuentes, {Hector A.} and Hausenloy, {Derek J.}",

note = "Publisher Copyright: {\textcopyright} 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license.",

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doi = "10.1016/j.ejphar.2015.04.056",

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journal = "European Journal of Pharmacology",

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AU - Ong, Sang Bing

AU - Kalkhoran, Siavash Beikoghli

AU - Cabrera-Fuentes, Hector A.

AU - Hausenloy, Derek J.

PY - 2015/9/15

Y1 - 2015/9/15

N2 - The past decade has witnessed a number of exciting developments in the field of mitochondrial dynamics - a phenomenon in which changes in mitochondrial shape and movement impact on cellular physiology and pathology. By undergoing fusion and fission, mitochondria are able to change their morphology between elongated interconnected networks and discrete fragmented structures, respectively. The cardiac mitochondria, in particular, have garnered much interest due to their unique spatial arrangement in the adult cardiomyocyte, and the multiple roles they play in cell death and survival. In this article, we review the role of the mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease.

AB - The past decade has witnessed a number of exciting developments in the field of mitochondrial dynamics - a phenomenon in which changes in mitochondrial shape and movement impact on cellular physiology and pathology. By undergoing fusion and fission, mitochondria are able to change their morphology between elongated interconnected networks and discrete fragmented structures, respectively. The cardiac mitochondria, in particular, have garnered much interest due to their unique spatial arrangement in the adult cardiomyocyte, and the multiple roles they play in cell death and survival. In this article, we review the role of the mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease.

KW - Drp1

KW - MFN1

KW - MFN2

KW - Mitochondrial fission

KW - Mitochondrial fusion

KW - OPA1

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M3 - Article

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AN - SCOPUS:84941600966

SN - 0014-2999

VL - 763

SP - 104

EP - 114

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

ER -

Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease

Abstract

Bibliographical note

Other keywords

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