Metastable decay of DNA components and their compositions - A perspective on the role of reactive electron scattering in radiation damage

H. D. Flosadóttir, B. Ómarsson, I. Bald, O. Ingólfsson*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Here we review recent studies on the metastable fragmentation of individual DNA and RNA building blocks and their compositions using matrix assisted laser desorption/ionization mass spectrometry (MALDI). To compare the fragmentation channels of small DNA components with larger compositions we have studied the metastable fragmentation of the deprotonated nucleobases, ribose, ribose-monophoshates, the nucleosides, the nucleoside 5'-monophosphates and selected oligonucleotides. Both previously published and unpublished data are reported. To gain a comprehensive picture of the fragmentation of individual components, metastable fragmentation of native components are in many cases compared to chemically modified components and isotopic labelling is used to unambiguously identify fragments. Furthermore, to shed light on the underlying fragmentation mechanisms we complement the experimental studies with classical dynamics simulations of the fragmentation of selected compounds. For the DNA and RNA components where dissociative electron attachment studies have been conducted we compare these to the metastable fragmentation channels observed here.

Original languageEnglish
Article number13
JournalEuropean Physical Journal D
Volume66
Issue number1
DOIs
Publication statusPublished - Jan 2012

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