Metabolomic profiling of samples from pediatric patients with asthma unveils deficient nutrients in African Americans

IHCC consortium

doi:10.1016/j.isci.2022.104650

Metabolomic profiling of samples from pediatric patients with asthma unveils deficient nutrients in African Americans

IHCC consortium

Research output: Contribution to journal › Article › peer-review

Abstract

Plasma metabolomics represents a potentially powerful approach to understand the biochemical mechanisms of nutrition and metabolism in asthma. This study aims to acquire knowledge on plasma metabolites in asthma, which may provide avenues for nutrition therapy, as well as explanations for the observed effects in existing therapies. This study investigated 249 metabolites from 18 metabolite groups in a large cohort of African American population, including 602 pediatric patients with asthma and 593 controls, using a nuclear magnetic resonance (NMR) metabolomics platform. Decreased levels of citrate, ketone bodies, and two amino acids histidine (His) and glutamine (Gln), were observed in asthma cases compared to controls. Metabolites for lipid metabolism lost significance after controlling for comorbid obesity. For the first time, this study depicts a broad panorama of lipid metabolism and nutrition in asthma. Supplementation or augmentation of nutrients that are deficient may be beneficial for asthma care.

Original language	English
Article number	104650
Journal	iScience
Volume	25
Issue number	7
DOIs	https://doi.org/10.1016/j.isci.2022.104650
Publication status	Published - 15 Jul 2022
Externally published	Yes

Bibliographical note

Funding Information:
We thank the patients and their families for their participation in the study. We thank Nightingale for their services. Funding: The study was supported by: The International Hundred Thousand Plus Cohort Consortium ( IHCC ); CHOP funding: Institutional Development Funds from the Children’s Hospital of Philadelphia to the Center for Applied Genomics, The Children’s Hospital of Philadelphia Endowed Chair in Genomic Research (HH). Grant/award number: Not applicable.

Publisher Copyright:
© 2022 The Authors

Other keywords

Ethnic issue
Metabolomics
Pediatrics
Respiratory medicine

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10.1016/j.isci.2022.104650

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title = "Metabolomic profiling of samples from pediatric patients with asthma unveils deficient nutrients in African Americans",

abstract = "Plasma metabolomics represents a potentially powerful approach to understand the biochemical mechanisms of nutrition and metabolism in asthma. This study aims to acquire knowledge on plasma metabolites in asthma, which may provide avenues for nutrition therapy, as well as explanations for the observed effects in existing therapies. This study investigated 249 metabolites from 18 metabolite groups in a large cohort of African American population, including 602 pediatric patients with asthma and 593 controls, using a nuclear magnetic resonance (NMR) metabolomics platform. Decreased levels of citrate, ketone bodies, and two amino acids histidine (His) and glutamine (Gln), were observed in asthma cases compared to controls. Metabolites for lipid metabolism lost significance after controlling for comorbid obesity. For the first time, this study depicts a broad panorama of lipid metabolism and nutrition in asthma. Supplementation or augmentation of nutrients that are deficient may be beneficial for asthma care.",

keywords = "Ethnic issue, Metabolomics, Pediatrics, Respiratory medicine",

author = "{IHCC consortium} and Qu, {Hui Qi} and Joseph Glessner and Jingchun Qu and Steven Gilhool and Frank Mentch and Ian Campbell and Patrick Sleiman and Connolly, {John J.} and Hakon Hakonarson",

note = "Funding Information: We thank the patients and their families for their participation in the study. We thank Nightingale for their services. Funding: The study was supported by: The International Hundred Thousand Plus Cohort Consortium ( IHCC ); CHOP funding: Institutional Development Funds from the Children{\textquoteright}s Hospital of Philadelphia to the Center for Applied Genomics, The Children{\textquoteright}s Hospital of Philadelphia Endowed Chair in Genomic Research (HH). Grant/award number: Not applicable. Publisher Copyright: {\textcopyright} 2022 The Authors",

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AU - Mentch, Frank

AU - Campbell, Ian

AU - Sleiman, Patrick

AU - Connolly, John J.

AU - Hakonarson, Hakon

N1 - Funding Information: We thank the patients and their families for their participation in the study. We thank Nightingale for their services. Funding: The study was supported by: The International Hundred Thousand Plus Cohort Consortium ( IHCC ); CHOP funding: Institutional Development Funds from the Children’s Hospital of Philadelphia to the Center for Applied Genomics, The Children’s Hospital of Philadelphia Endowed Chair in Genomic Research (HH). Grant/award number: Not applicable. Publisher Copyright: © 2022 The Authors

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AB - Plasma metabolomics represents a potentially powerful approach to understand the biochemical mechanisms of nutrition and metabolism in asthma. This study aims to acquire knowledge on plasma metabolites in asthma, which may provide avenues for nutrition therapy, as well as explanations for the observed effects in existing therapies. This study investigated 249 metabolites from 18 metabolite groups in a large cohort of African American population, including 602 pediatric patients with asthma and 593 controls, using a nuclear magnetic resonance (NMR) metabolomics platform. Decreased levels of citrate, ketone bodies, and two amino acids histidine (His) and glutamine (Gln), were observed in asthma cases compared to controls. Metabolites for lipid metabolism lost significance after controlling for comorbid obesity. For the first time, this study depicts a broad panorama of lipid metabolism and nutrition in asthma. Supplementation or augmentation of nutrients that are deficient may be beneficial for asthma care.

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Metabolomic profiling of samples from pediatric patients with asthma unveils deficient nutrients in African Americans

Abstract

Bibliographical note

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