Menopause as a predictor of new-onset asthma: A longitudinal Northern European population study

Kai Triebner; Ane Johannessen; Luca Puggini; Bryndís Benediktsdóttir; Randi J Bertelsen; Ersilia Bifulco; Shyamali C Dharmage; Julia Dratva; Karl A Franklin; Thórarinn Gíslason; Mathias Holm; Deborah Jarvis; Bénédicte Leynaert; Eva Lindberg; Andrei Malinovschi; Ferenc Macsali; Dan Norbäck; Ernst R Omenaas; Francisco J Rodríguez; Eirunn Saure; Vivi Schlünssen; Torben Sigsgaard; Trude D Skorge; Gunilla Wieslander; Elisabeth Zemp; Cecilie Svanes; Steinar Hustad; Francisco Gómez Real

doi:10.1016/j.jaci.2015.08.019

Menopause as a predictor of new-onset asthma: A longitudinal Northern European population study

Kai Triebner, Ane Johannessen, Luca Puggini, Bryndís Benediktsdóttir, Randi J Bertelsen, Ersilia Bifulco, Shyamali C Dharmage, Julia Dratva, Karl A Franklin, Thórarinn Gíslason, Mathias Holm, Deborah Jarvis, Bénédicte Leynaert, Eva Lindberg, Andrei Malinovschi, Ferenc Macsali, Dan Norbäck, Ernst R Omenaas, Francisco J Rodríguez, Eirunn SaureVivi Schlünssen, Torben Sigsgaard, Trude D Skorge, Gunilla Wieslander, Elisabeth Zemp, Cecilie Svanes, Steinar Hustad, Francisco Gómez Real

Research output: Contribution to journal › Article › peer-review

Abstract

There is limited and conflicting evidence on the effect of menopause on asthma.
We sought to study whether the incidence of asthma and respiratory symptoms differ by menopausal status in a longitudinal population-based study with an average follow-up of 12 years.
The Respiratory Health in Northern Europe study provided questionnaire data pertaining to respiratory and reproductive health at baseline (1999-2001) and follow-up (2010-2012). The study cohort included women aged 45 to 65 years at follow-up, without asthma at baseline, and not using exogenous hormones (n = 2322). Menopausal status was defined as nonmenopausal, transitional, early postmenopausal, and late postmenopausal. Associations with asthma (defined by the use of asthma medication, having asthma attacks, or both) and respiratory symptoms scores were analyzed by using logistic (asthma) and negative binomial (respiratory symptoms) regressions, adjusting for age, body mass index, physical activity, smoking, education, and study center.
The odds of new-onset asthma were increased in women who were transitional (odds ratio, 2.40; 95% CI, 1.09-5.30), early postmenopausal (odds ratio, 2.11; 95% CI, 1.06-4.20), and late postmenopausal (odds ratio, 3.44; 95% CI, 1.31-9.05) at follow-up compared with nonmenopausal women. The risk of respiratory symptoms increased in early postmenopausal (coefficient, 0.40; 95% CI, 0.06-0.75) and late postmenopausal (coefficient, 0.69; 95% CI, 0.15-1.23) women. These findings were consistent irrespective of smoking status and across study centers.
New-onset asthma and respiratory symptoms increased in women becoming postmenopausal in a longitudinal population-based study. Clinicians should be aware that respiratory health might deteriorate in women during reproductive aging.

Original language	English
Journal	The Journal of allergy and clinical immunology
Volume	137
Issue number	1
DOIs	https://doi.org/10.1016/j.jaci.2015.08.019
Publication status	Published - Jan 2016

Other keywords

Asma
Tíðahvörf
PAD12
Amenorrhea
Asthma
Estrogens
Longitudinal Studies
Menopause
Aging
Signs and Symptoms, Respiratory
Gonadal Steroid Hormones

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10.1016/j.jaci.2015.08.019

http://dx.doi.org/ 10.1016/j.jaci.2015.08.019

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Triebner, K., Johannessen, A., Puggini, L., Benediktsdóttir, B., Bertelsen, R. J., Bifulco, E., Dharmage, S. C., Dratva, J., Franklin, K. A., Gíslason, T., Holm, M., Jarvis, D., Leynaert, B., Lindberg, E., Malinovschi, A., Macsali, F., Norbäck, D., Omenaas, E. R., Rodríguez, F. J., ... Gómez Real, F. (2016). Menopause as a predictor of new-onset asthma: A longitudinal Northern European population study. The Journal of allergy and clinical immunology, 137(1). https://doi.org/10.1016/j.jaci.2015.08.019

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abstract = "There is limited and conflicting evidence on the effect of menopause on asthma.We sought to study whether the incidence of asthma and respiratory symptoms differ by menopausal status in a longitudinal population-based study with an average follow-up of 12 years.The Respiratory Health in Northern Europe study provided questionnaire data pertaining to respiratory and reproductive health at baseline (1999-2001) and follow-up (2010-2012). The study cohort included women aged 45 to 65 years at follow-up, without asthma at baseline, and not using exogenous hormones (n = 2322). Menopausal status was defined as nonmenopausal, transitional, early postmenopausal, and late postmenopausal. Associations with asthma (defined by the use of asthma medication, having asthma attacks, or both) and respiratory symptoms scores were analyzed by using logistic (asthma) and negative binomial (respiratory symptoms) regressions, adjusting for age, body mass index, physical activity, smoking, education, and study center.The odds of new-onset asthma were increased in women who were transitional (odds ratio, 2.40; 95% CI, 1.09-5.30), early postmenopausal (odds ratio, 2.11; 95% CI, 1.06-4.20), and late postmenopausal (odds ratio, 3.44; 95% CI, 1.31-9.05) at follow-up compared with nonmenopausal women. The risk of respiratory symptoms increased in early postmenopausal (coefficient, 0.40; 95% CI, 0.06-0.75) and late postmenopausal (coefficient, 0.69; 95% CI, 0.15-1.23) women. These findings were consistent irrespective of smoking status and across study centers.New-onset asthma and respiratory symptoms increased in women becoming postmenopausal in a longitudinal population-based study. Clinicians should be aware that respiratory health might deteriorate in women during reproductive aging.",

keywords = "Asma, T{\'i}{\dh}ahv{\"o}rf, PAD12, Amenorrhea, Asthma, Estrogens, Longitudinal Studies, Menopause, Aging, Signs and Symptoms, Respiratory, Gonadal Steroid Hormones, Asma, T{\'i}{\dh}ahv{\"o}rf, PAD12, Amenorrhea, Asthma, Estrogens, Longitudinal Studies, Menopause, Aging, Signs and Symptoms, Respiratory, Gonadal Steroid Hormones",

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language = "English",

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Triebner, K, Johannessen, A, Puggini, L, Benediktsdóttir, B, Bertelsen, RJ, Bifulco, E, Dharmage, SC, Dratva, J, Franklin, KA, Gíslason, T, Holm, M, Jarvis, D, Leynaert, B, Lindberg, E, Malinovschi, A, Macsali, F, Norbäck, D, Omenaas, ER, Rodríguez, FJ, Saure, E, Schlünssen, V, Sigsgaard, T, Skorge, TD, Wieslander, G, Zemp, E, Svanes, C, Hustad, S & Gómez Real, F 2016, 'Menopause as a predictor of new-onset asthma: A longitudinal Northern European population study', The Journal of allergy and clinical immunology, vol. 137, no. 1. https://doi.org/10.1016/j.jaci.2015.08.019

TY - JOUR

T1 - Menopause as a predictor of new-onset asthma: A longitudinal Northern European population study

AU - Triebner, Kai

AU - Johannessen, Ane

AU - Puggini, Luca

AU - Benediktsdóttir, Bryndís

AU - Bertelsen, Randi J

AU - Bifulco, Ersilia

AU - Dharmage, Shyamali C

AU - Dratva, Julia

AU - Franklin, Karl A

AU - Gíslason, Thórarinn

AU - Holm, Mathias

AU - Jarvis, Deborah

AU - Leynaert, Bénédicte

AU - Lindberg, Eva

AU - Malinovschi, Andrei

AU - Macsali, Ferenc

AU - Norbäck, Dan

AU - Omenaas, Ernst R

AU - Rodríguez, Francisco J

AU - Saure, Eirunn

AU - Schlünssen, Vivi

AU - Sigsgaard, Torben

AU - Skorge, Trude D

AU - Wieslander, Gunilla

AU - Zemp, Elisabeth

AU - Svanes, Cecilie

AU - Hustad, Steinar

AU - Gómez Real, Francisco

PY - 2016/1

Y1 - 2016/1

N2 - There is limited and conflicting evidence on the effect of menopause on asthma.We sought to study whether the incidence of asthma and respiratory symptoms differ by menopausal status in a longitudinal population-based study with an average follow-up of 12 years.The Respiratory Health in Northern Europe study provided questionnaire data pertaining to respiratory and reproductive health at baseline (1999-2001) and follow-up (2010-2012). The study cohort included women aged 45 to 65 years at follow-up, without asthma at baseline, and not using exogenous hormones (n = 2322). Menopausal status was defined as nonmenopausal, transitional, early postmenopausal, and late postmenopausal. Associations with asthma (defined by the use of asthma medication, having asthma attacks, or both) and respiratory symptoms scores were analyzed by using logistic (asthma) and negative binomial (respiratory symptoms) regressions, adjusting for age, body mass index, physical activity, smoking, education, and study center.The odds of new-onset asthma were increased in women who were transitional (odds ratio, 2.40; 95% CI, 1.09-5.30), early postmenopausal (odds ratio, 2.11; 95% CI, 1.06-4.20), and late postmenopausal (odds ratio, 3.44; 95% CI, 1.31-9.05) at follow-up compared with nonmenopausal women. The risk of respiratory symptoms increased in early postmenopausal (coefficient, 0.40; 95% CI, 0.06-0.75) and late postmenopausal (coefficient, 0.69; 95% CI, 0.15-1.23) women. These findings were consistent irrespective of smoking status and across study centers.New-onset asthma and respiratory symptoms increased in women becoming postmenopausal in a longitudinal population-based study. Clinicians should be aware that respiratory health might deteriorate in women during reproductive aging.

AB - There is limited and conflicting evidence on the effect of menopause on asthma.We sought to study whether the incidence of asthma and respiratory symptoms differ by menopausal status in a longitudinal population-based study with an average follow-up of 12 years.The Respiratory Health in Northern Europe study provided questionnaire data pertaining to respiratory and reproductive health at baseline (1999-2001) and follow-up (2010-2012). The study cohort included women aged 45 to 65 years at follow-up, without asthma at baseline, and not using exogenous hormones (n = 2322). Menopausal status was defined as nonmenopausal, transitional, early postmenopausal, and late postmenopausal. Associations with asthma (defined by the use of asthma medication, having asthma attacks, or both) and respiratory symptoms scores were analyzed by using logistic (asthma) and negative binomial (respiratory symptoms) regressions, adjusting for age, body mass index, physical activity, smoking, education, and study center.The odds of new-onset asthma were increased in women who were transitional (odds ratio, 2.40; 95% CI, 1.09-5.30), early postmenopausal (odds ratio, 2.11; 95% CI, 1.06-4.20), and late postmenopausal (odds ratio, 3.44; 95% CI, 1.31-9.05) at follow-up compared with nonmenopausal women. The risk of respiratory symptoms increased in early postmenopausal (coefficient, 0.40; 95% CI, 0.06-0.75) and late postmenopausal (coefficient, 0.69; 95% CI, 0.15-1.23) women. These findings were consistent irrespective of smoking status and across study centers.New-onset asthma and respiratory symptoms increased in women becoming postmenopausal in a longitudinal population-based study. Clinicians should be aware that respiratory health might deteriorate in women during reproductive aging.

KW - Asma

KW - Tíðahvörf

KW - PAD12

KW - Amenorrhea

KW - Asthma

KW - Estrogens

KW - Longitudinal Studies

KW - Menopause

KW - Aging

KW - Signs and Symptoms, Respiratory

KW - Gonadal Steroid Hormones

KW - Asma

KW - Tíðahvörf

KW - PAD12

KW - Amenorrhea

KW - Asthma

KW - Estrogens

KW - Longitudinal Studies

KW - Menopause

KW - Aging

KW - Signs and Symptoms, Respiratory

KW - Gonadal Steroid Hormones

U2 - 10.1016/j.jaci.2015.08.019

DO - 10.1016/j.jaci.2015.08.019

M3 - Article

C2 - 26435006

SN - 1097-6825

VL - 137

JO - The Journal of allergy and clinical immunology

JF - The Journal of allergy and clinical immunology

IS - 1

ER -

Menopause as a predictor of new-onset asthma: A longitudinal Northern European population study

Abstract

Other keywords

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