Meningeal melanocytes in the mouse: Distribution and dependence on mitf

Stefán A.H. Gudjohnsen; Diahann A.M. Atacho; Franck Gesbert; Graca Raposo; Ilse Hurbain; Lionel Larue; Eirikur Steingrimsson; Petur Henry Petersen

doi:10.3389/fnana.2015.00149

Meningeal melanocytes in the mouse: Distribution and dependence on mitf

Stefán A.H. Gudjohnsen, Diahann A.M. Atacho, Franck Gesbert, Graca Raposo, Ilse Hurbain, Lionel Larue, Eirikur Steingrimsson^*, Petur Henry Petersen

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Melanocytes are pigment producing cells derived from the neural crest. They are primarily found in the skin and hair follicles, but can also be found in other tissues including the eye, ear and heart. Here, we describe the distribution of pigmented cells in C57BL/6J mouse meninges, the membranes that envelope the brain. These cells contain melanosomes of all four stages of development and they depend on Microphthalmia associated transcription factor (MITF), the master regulator ofmelanocyte development, suggesting that they are bona-fide melanocytes. The location of these pigmented cells is consistent with the location of meningeal melanomas in humans and animal models. Significance: Here, we document and define pigmented cells in the meninges of the mouse brain and confirm that they are melanocytes. This is important for understanding the role of this cell type and for understanding primary meningeal melanoma, a rare

Original language	English
Article number	A149
Pages (from-to)	1-8
Number of pages	8
Journal	Frontiers in Neuroanatomy
Volume	9
Issue number	November
DOIs	https://doi.org/10.3389/fnana.2015.00149
Publication status	Published - 25 Nov 2015

Bibliographical note

Publisher Copyright:
© 2015 Gudjohnsen, Atacho, Gesbert, Raposo, Hurbain, Larue, Steingrimsson and Petersen.

Other keywords

Melanocytes
Meningeal melanoma
Meninges
Mitf
Mouse

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10.3389/fnana.2015.00149

Cite this

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title = "Meningeal melanocytes in the mouse: Distribution and dependence on mitf",

abstract = "Melanocytes are pigment producing cells derived from the neural crest. They are primarily found in the skin and hair follicles, but can also be found in other tissues including the eye, ear and heart. Here, we describe the distribution of pigmented cells in C57BL/6J mouse meninges, the membranes that envelope the brain. These cells contain melanosomes of all four stages of development and they depend on Microphthalmia associated transcription factor (MITF), the master regulator ofmelanocyte development, suggesting that they are bona-fide melanocytes. The location of these pigmented cells is consistent with the location of meningeal melanomas in humans and animal models. Significance: Here, we document and define pigmented cells in the meninges of the mouse brain and confirm that they are melanocytes. This is important for understanding the role of this cell type and for understanding primary meningeal melanoma, a rare",

keywords = "Melanocytes, Meningeal melanoma, Meninges, Mitf, Mouse",

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AU - Gudjohnsen, Stefán A.H.

AU - Atacho, Diahann A.M.

AU - Gesbert, Franck

AU - Raposo, Graca

AU - Hurbain, Ilse

AU - Larue, Lionel

AU - Steingrimsson, Eirikur

AU - Petersen, Petur Henry

PY - 2015/11/25

Y1 - 2015/11/25

N2 - Melanocytes are pigment producing cells derived from the neural crest. They are primarily found in the skin and hair follicles, but can also be found in other tissues including the eye, ear and heart. Here, we describe the distribution of pigmented cells in C57BL/6J mouse meninges, the membranes that envelope the brain. These cells contain melanosomes of all four stages of development and they depend on Microphthalmia associated transcription factor (MITF), the master regulator ofmelanocyte development, suggesting that they are bona-fide melanocytes. The location of these pigmented cells is consistent with the location of meningeal melanomas in humans and animal models. Significance: Here, we document and define pigmented cells in the meninges of the mouse brain and confirm that they are melanocytes. This is important for understanding the role of this cell type and for understanding primary meningeal melanoma, a rare

AB - Melanocytes are pigment producing cells derived from the neural crest. They are primarily found in the skin and hair follicles, but can also be found in other tissues including the eye, ear and heart. Here, we describe the distribution of pigmented cells in C57BL/6J mouse meninges, the membranes that envelope the brain. These cells contain melanosomes of all four stages of development and they depend on Microphthalmia associated transcription factor (MITF), the master regulator ofmelanocyte development, suggesting that they are bona-fide melanocytes. The location of these pigmented cells is consistent with the location of meningeal melanomas in humans and animal models. Significance: Here, we document and define pigmented cells in the meninges of the mouse brain and confirm that they are melanocytes. This is important for understanding the role of this cell type and for understanding primary meningeal melanoma, a rare

KW - Melanocytes

KW - Meningeal melanoma

KW - Meninges

KW - Mitf

KW - Mouse

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JF - Frontiers in Neuroanatomy

IS - November

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ER -

Meningeal melanocytes in the mouse: Distribution and dependence on mitf

Abstract

Bibliographical note

Other keywords

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