Maternal diet, gestational weight gain, and inflammatory markers during pregnancy

Laufey Hrolfsdottir*, Casper G. Schalkwijk, Bryndis E. Birgisdottir, Ingibjorg Gunnarsdottir, Ekaterina Maslova, Charlotta Granström, Marin Strøm, Sjurdur F. Olsen, Thorhallur I. Halldorsson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Objective: To examine the associations of gestational weight gain (GWG) and diet with low-grade inflammation in pregnancy. Methods: A cross-sectional analysis of 671 pregnant women was performed, and diet was assessed in gestational week 30. GWG was recorded in weeks 30 and ∼37 (difference between the weight recorded at these time points and pre-pregnancy weight). Markers of inflammation, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), interleukin (IL)−6, IL-8, IL-1β, and tumor necrosis factor-α were quantified in serum from week 30. Results: After adjusting for age, pre-pregnancy BMI, parity, smoking status, and education, each 1 kg increase in GWG was associated with 3% (95% CI: 1–5) higher hsCRP and 3% (95% CI: 1–4) higher SAA concentrations, which corresponded to ∼18% to 25% increase in these biomarkers among those with excessive weight gain. GWG was inversely associated with IL-8 while no associations were found for the other inflammatory markers. With respect to diet, women in the highest compared with lowest quintile of protein intake had 26% (95% CI: 3–54) higher hsCRP concentrations. This increase appeared to be driven by intake of animal protein. A similar pattern was observed for SAA. Conclusions: Excessive GWG, as well as high intake of animal protein, was associated with higher concentrations of inflammatory factors.

Original languageEnglish
Pages (from-to)2133-2139
Number of pages7
Issue number10
Publication statusPublished - 1 Oct 2016

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© 2016 The Obesity Society


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