Male-pattern baldness susceptibility locus at 20p11

J. Brent Richards, Xin Yuan, Frank Geller, Dawn Waterworth, Veronique Bataille, Daniel Glass, Kijoung Song, Gerard Waeber, Peter Vollenweider, Katja K.H. Aben, Lambertus A. Kiemeney, Bragi Walters, Nicole Soranzo, Unnur Thorsteinsdottir, Augustine Kong, Thorunn Rafnar, Panos Deloukas, Patrick Sulem, Hreinn Stefansson, Kari StefanssonTim D. Spector, Vincent Mooser

Research output: Contribution to journalArticlepeer-review

Abstract

We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 × 10-14 for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 × 10-15).

Original languageEnglish
Pages (from-to)1282-1284
Number of pages3
JournalNature Genetics
Volume40
Issue number11
DOIs
Publication statusPublished - Nov 2008

Bibliographical note

Funding Information:
We wish to acknowledge the cooperation and dedication of the study participants and the personnel at the recruitment centers and core facilities. We would like to acknowledge the genotyping contributions of D. Smyth and J. Todd. This study was funded in part by GlaxoSmithKline; deCODE Genetics; the Wellcome Trust; NIHR Biomedical Research Centre (grant to Guys’ and St. Thomas’ Hospitals and King’s College London); the Chronic Disease Research Foundation; the Canadian Institutes of Health Research (J.B.R.) and the Sixth Framework Program of the EU contract number 018827 (Polygene).

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