Male-female differences in the association between incident hip fracture and proximal femoral strength: A finite element analysis study

J. H. Keyak*, S. Sigurdsson, G. Karlsdottir, D. Oskarsdottir, A. Sigmarsdottir, S. Zhao, J. Kornak, T. B. Harris, G. Sigurdsson, B. Y. Jonsson, K. Siggeirsdottir, G. Eiriksdottir, V. Gudnason, T. F. Lang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

113 Citations (Scopus)


Hip fracture risk is usually evaluated using dual energy X-ray absorptiometry (DXA) or quantitative computed tomography (QCT) which provide surrogate measures for proximal femoral strength. However, proximal femoral strength can best be estimated explicitly by combining QCT with finite element (FE) analysis. To evaluate this technique for predicting hip fracture in older men and women, we performed a nested age- and sex-matched case-control study in the Age Gene/Environment Susceptibility (AGES) Reykjavik cohort. Baseline (pre-fracture) QCT scans of 5500 subjects were obtained. During 4-7years follow-up, 51 men and 77 women sustained hip fractures. Ninety-seven men and 152 women were randomly selected as age- and sex-matched controls. FE-strength of the left hip of each subject for stance (FStance) and posterolateral fall (FFall) loading, and total femur areal bone mineral density (aBMD) were computed from the QCT data. FStance and FFall in incident hip fracture subjects were 13%-25% less than in control subjects (p≤0.006) after controlling for demographic parameters. The difference between FE strengths of fracture and control subjects was disproportionately greater in men (stance, 22%; fall, 25%) than in women (stance, 13%; fall, 18%) (p≤0.033), considering that FStance and FFall in fracture subjects were greater in men than in women (p<0.001). For men, FStance was associated with hip fracture after accounting for aBMD (p=0.013). These data indicate that FStance provides information about fracture risk that is beyond that provided by aBMD (p=0.013). These findings support further exploration of possible sex differences in the predictors of hip fracture and of sex-specific strategies for using FE analysis to manage osteoporosis.

Original languageEnglish
Pages (from-to)1239-1245
Number of pages7
Issue number6
Publication statusPublished - 1 Jun 2011

Bibliographical note

Funding Information:
This study was supported by NIH/NIA R01AG028832 and NIH/NIAMS R01AR46197 . The Age, Gene/Environment Susceptibility Reykjavik Study is funded by NIH contract N01-AG-12100 , the NIA Intramural Research Program , Hjartavernd (the Icelandic Heart Association), and the Althingi (the Icelandic Parliament). The study was approved by the Icelandic National Bioethics Committee, (VSN: 00–063) and the Data Protection Authority. The researchers are indebted to the participants for their willingness to participate in the study.

Other keywords

  • Bone strength
  • Femur
  • Finite element analysis
  • Hip fracture
  • Osteoporosis
  • Quantitative computed tomography


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