Magnetization transfer imaging, white matter hyperintensities, brain atrophy and slower gait in older men and women

Caterina Rosano*, Sigurdur Sigurdsson, Kristin Siggeirsdottir, Caroline L. Phillips, Melissa Garcia, Palmi V. Jonsson, Gudny Eiriksdottir, Anne B. Newman, Tamara B. Harris, Mark A. van Buchem, Vilmundur Gudnason, Lenore J. Launer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)

Abstract

Objective: To assess whether markers of micro- and macrostructural brain abnormalities are associated with slower gait in older men and women independent of each other, and also independent of health-related conditions and of behavioral, cognitive and peripheral function. Methods: Magnetization transfer ratio [MTR], white matter hyperintensities [WMH], brain atrophy [BA] and brain infarcts [BI] were measured in 795 participants of the AGES-Reykjavik Study cohort (. mean 75.6 years, 58.9% women). Results: In women, lower MTR, higher WMH and BA, but not BI, remained associated with slower gait independent of each other and of other covariates. In men, WMH and BA, but not MTR or BI, remained associated with slower gait independently of each other. Only muscle strength, executive control function and depression test scores substantially attenuated these associations. Interpretations: MTR in older adults may be an important additional marker of brain abnormalities associated with slower gait. Studies to explore the relationship between brain micro- and macrostructural abnormalities with gait and the role of mediating factors are warranted.

Original languageEnglish
Pages (from-to)1197-1204
Number of pages8
JournalNeurobiology of Aging
Volume31
Issue number7
DOIs
Publication statusPublished - Jul 2010

Bibliographical note

Funding Information:
This study has been funded by the Icelandic Heart Association , by NIH contract N01-AG-12100 and is supported in part by the Intramural Research Program of the National Institute on Aging. Dr. Rosano is funded by 1K23 AG 028966-01 , R03 AG 025076-01A1 , 1 R01 AG029232-01 , 1 P30 AG024827 .

Other keywords

  • Community-dwelling seniors
  • Gait speed
  • MTR

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