Lung function in patients with systemic lupus erythematosus and persistent chest symptoms

H. Jonsson*, O. Nived, G. Sturfelt, S. Valind, B. Jonson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Twelve consecutive patients with systemic lupus erythematosus (SLE) and chest symptoms of at least 3 months' duration were investigated with spirometry, lung mechanics at rest and exercise, diffusion apacity and right heart catheterization. Vital capacity (88% of predicted, p≪0.05), and FEV1 (84%, p≪0.01) were decreased in the study group, but spirometric and diffusion capacity abnormalities were moderate compared with previous studies. The single breath CO2 test showed, in six patients, ventilation-perfusion mismatch with patterns typical for either bronchia] obstruction or vascular disease. Non-respiratory factors were responsible for reduction of working capacity (on average 68% of predicted normal values (p≪0.001)). Two patients with pulmonary hypertension were identified by right heart :atheterization. One of them had overlap features with the CREST syndrome. Both these patients had abnormal SBT-CO2 test and diffusion capacity, along with diffuse perfusion defects on perfusion scintigraphy.The low frequency of pulmonary function abnormalities in this study suggests that irreversible pulmonary damage is uncommon in SLE.

Original languageEnglish
Pages (from-to)492-499
Number of pages8
Issue number6
Publication statusPublished - Dec 1989

Bibliographical note

Funding Information:
This study was supported by the Swedish National Association against Chest and Heart Diseases and the Swedish Medical Research Council (grant number 02872). It was also supported by grants from Alfred Osterlunds Stiftelse, Greta och Johan Kocks Stiftelser, Konung Gustaf V: s 80-arsfond, Lunds Sjukvardsdistrikt, Stiftelsen Bistand fit Vanfora i Skane, The Medical Faculty of the University of Lund, and Crafoordska Stiftelsen.

Other keywords

  • Perfusion
  • Pulmonary hypertension
  • SLE
  • Ventilation


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