Loss of heterozygosity at chromosome 7q in human breast cancer: Association with clinical variables

Árni Kjalar Kristjánsson, Gudny Eiriksdottir, Gisli Ragnarsson, Asgeir Sigurdsson, Julius Gudmundsson, Rosa Bjork Barkardottir, Jon G. Jonasson, Valgardur Egilsson, Sigurdur Ingvarsson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


In this study 238 human primary breast cancers were analysed with 9 polymorphic microsatellite markers specific to region 7q21-q35 on chromosome 7. LOH was observed at one or more marker in 82 cases or (34%). The deletions were evenly distributed throughout the region. Patients were divided into two groups according to whether LOH was observed in their tumours or not, and tested for association with overall survival, the clinicopathological features: steroid receptor content, tumour size, node status, DNA ploidy and S-phase fraction, and LOH at other chromosomal regions. An association as found between 7q LOH and high S-phase fraction. An association was found between LOH at 7q and LOH at lp, 3p, 9p, 13q and 17q. These results suggest the location of a putative tumour suppressor gene at chromosome 7q21-q35 that, in combination with other deletions, might enhance tumour growth.

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalAnticancer Research
Issue number1 A
Publication statusPublished - 1997

Other keywords

  • Breast cancer
  • Chromosome 7q
  • Clinicopathology
  • Loss of heterozygosity,
  • Tumor suppressor genes


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