TY - JOUR
T1 - Loss of heterozygosity at chromosome 7q in human breast cancer
T2 - Association with clinical variables
AU - Kristjánsson, Árni Kjalar
AU - Eiriksdottir, Gudny
AU - Ragnarsson, Gisli
AU - Sigurdsson, Asgeir
AU - Gudmundsson, Julius
AU - Barkardottir, Rosa Bjork
AU - Jonasson, Jon G.
AU - Egilsson, Valgardur
AU - Ingvarsson, Sigurdur
PY - 1997
Y1 - 1997
N2 - In this study 238 human primary breast cancers were analysed with 9 polymorphic microsatellite markers specific to region 7q21-q35 on chromosome 7. LOH was observed at one or more marker in 82 cases or (34%). The deletions were evenly distributed throughout the region. Patients were divided into two groups according to whether LOH was observed in their tumours or not, and tested for association with overall survival, the clinicopathological features: steroid receptor content, tumour size, node status, DNA ploidy and S-phase fraction, and LOH at other chromosomal regions. An association as found between 7q LOH and high S-phase fraction. An association was found between LOH at 7q and LOH at lp, 3p, 9p, 13q and 17q. These results suggest the location of a putative tumour suppressor gene at chromosome 7q21-q35 that, in combination with other deletions, might enhance tumour growth.
AB - In this study 238 human primary breast cancers were analysed with 9 polymorphic microsatellite markers specific to region 7q21-q35 on chromosome 7. LOH was observed at one or more marker in 82 cases or (34%). The deletions were evenly distributed throughout the region. Patients were divided into two groups according to whether LOH was observed in their tumours or not, and tested for association with overall survival, the clinicopathological features: steroid receptor content, tumour size, node status, DNA ploidy and S-phase fraction, and LOH at other chromosomal regions. An association as found between 7q LOH and high S-phase fraction. An association was found between LOH at 7q and LOH at lp, 3p, 9p, 13q and 17q. These results suggest the location of a putative tumour suppressor gene at chromosome 7q21-q35 that, in combination with other deletions, might enhance tumour growth.
KW - Breast cancer
KW - Chromosome 7q
KW - Clinicopathology
KW - Loss of heterozygosity,
KW - Tumor suppressor genes
UR - http://www.scopus.com/inward/record.url?scp=0031048452&partnerID=8YFLogxK
M3 - Article
C2 - 9066635
AN - SCOPUS:0031048452
SN - 0250-7005
VL - 17
SP - 93
EP - 98
JO - Anticancer Research
JF - Anticancer Research
IS - 1 A
ER -