Light chain ratios and concentrations of serum immunoglobulins in children with epilepsy

Ásgeir Haraldsson*, Baziel G.M. van Engelen, Willy O. Renier, Jan A.J.M. Bakkeren, Corry M.R. Weemaes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Serum immunoglobulin G, A and M concentrations and their respective kappa/lambda (κ/gl) light chain ratios were studied in 26 children with epilepsy. Fifteen had cryptogenic West syndrome or Lennox-Gastaut syndrome and 11 had other forms of childhood epilepsy. The results were compared to the data of a reference group of healthy children. The mean serum IgG and IgM concentrations were respectively 2.2 g/1 (P = 0.007) and 0.4 g/1 (P = 0.016) higher in the 26 children with epilepsy compared to the reference group. The κ/λ ratios of total serum immunoglobulins, IgG and IgM were respectively 0.10 (P = 0.057), 0.20 (P = 0.001) and 0.14 (P = 0.005) lower in the children with epilepsy than in the reference group. IgA concentration and IgA κ/λ ratio were not affected. There were no significant differences between the κ/gl ratios of the West and Lennox-Gastaut epilepsy and the other types of childhood epilepsies. The results are further evidence of reciprocal interaction between the nervous system and the immune system in childhood epilepsy.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalEpilepsy Research
Issue number3
Publication statusPublished - Dec 1992

Other keywords

  • Childhood epilepsy
  • Lennox-Gastaut syndrome
  • Light chains
  • West syndrome


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