Krabbamein hjá börnum á Íslandi árin 1981-2006

Trausti Óskarsson; Ólafur Gísli Jónsson; Jón R. Kristinsson; Guðmundur K. Jónmundsson; Jón Gunnlaugur Jónasson; Ásgeir Haraldsson

Krabbamein hjá börnum á Íslandi árin 1981-2006

Trausti Óskarsson, Ólafur Gísli Jónsson, Jón R. Kristinsson, Guðmundur K. Jónmundsson, Jón Gunnlaugur Jónasson, Ásgeir Haraldsson

Landspitali - The National University Hospital of Iceland

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Childhood cancer is the second most common cause of death in children. The aim of this study was to gather epidemiological information on childhood cancer in Iceland. METHODS: The study was population based and included all children younger than 18 years of age, diagnosed with cancer in Iceland from 1981 to 2006. Information was extracted from the Icelandic Cancer Registry and patient hospital records. RESULTS: During the study period 288 cancer cases were diagnosed in 279 children, 10 cases were secondary neoplasms. Age standardized incidence was 16.1 per 100.000 (95% CI 13,6-18,6) for boys and 12.8 per 100.000 (95% CI 10,5-15,0) for girls. There was no significant difference in the incidence rate between the first and second half of the study period. For children aged 0-14 years, the age standardized incidence was 13.6 per 100.000. The incidence was highest in the 0-4 year age group (17.3 per 100.000) and in the 15-17 year age group (19.6 per 100.000). Brain tumors (27.1%) and leukemia (25.0%) were the most common cancer groups diagnosed. Lymphoid leukemia was the most common cancer type (17.9%) and astrocytoma (13.1%) came second. CONCLUSIONS: The incidence of childhood cancer in Iceland is similar to other Western countries. Long-term follow-up is very important in childhood cancer survivors.
Inngangur: Krabbamein er næst algengasta dánarorsök barna á eftir slysum. Tilgangur rann-sóknarinnar var að kanna nýgengi krabbameina hjá börnum á Íslandi.  Aðferðir: Rannsóknin var lýðgrunduð og náði til allra <18 ára sem greindust með krabbamein á Íslandi frá upphafi árs 1981 til ársloka 2006. Upplýsingum var safnað frá Krabbameinsskrá Íslands og úr sjúkraskrám.  Niðurstöður: Alls greindust 288 krabbameinstilfelli á tímabilinu hjá 279 börnum. Í 10 tilvikum var um meðferðartengd krabbamein að ræða. Árlegt aldursstaðlað nýgengi hjá drengjum var 16,1 af 100.000 (95% CI; 13,6-18,6) en hjá stúlkum 12,8 af 100.000 (95% CI; 10,5-15,0) en ekki var marktækur munur á nýgengi milli fyrri og seinni hluta rannsóknartímabilsins. Fyrir aldursbilið 0-14 ára var árlegt aldursstaðlað nýgengi 13,6 af 100.000. Miðtaugakerfisæxli og hvítblæði voru samanlagt 52,1% allra krabbameinstilvika. Algengasta grein-ingin var bráða eitilfrumuhvítblæði (17,9%) og stjarnfrumnaæxli (13,1%) næstalgengust. Nýgeng-ið var hæst hjá aldursbilunum 0-4 ára (17,3 af 100.00) og 15-17 ára (19,6 af 100.000). Tíu börn voru með þekkta meðfædda áhættuþætti.  Ályktun: Nýgengi krabbameina hjá börnum á Íslandi er sambærilegt við nágrannalöndin. Mikilvægt er að fylgja vel eftir börnum sem gengið hafa í gegnum krabbameinsmeðferð og þeim sem hafa þekkta meðfædda áhættuþætti.   

Original language	Icelandic
Journal	Læknablaðið
Publication status	Published - 1 Jan 2010

Other keywords

Börn
Krabbamein
Adolescent
Age Distribution
Child
Child, Preschool
Female
Humans
Iceland
Incidence
Infant
Infant, Newborn
Male
Neoplasms
Registries
Sex Distribution
Time Factors

Access to Document

http://www.laeknabladid.is

Cite this

@article{a9719c44463a45a1abdc189e4d4ae053,

title = "Krabbamein hj{\'a} b{\"o}rnum {\'a} {\'I}slandi {\'a}rin 1981-2006",

abstract = "BACKGROUND: Childhood cancer is the second most common cause of death in children. The aim of this study was to gather epidemiological information on childhood cancer in Iceland. METHODS: The study was population based and included all children younger than 18 years of age, diagnosed with cancer in Iceland from 1981 to 2006. Information was extracted from the Icelandic Cancer Registry and patient hospital records. RESULTS: During the study period 288 cancer cases were diagnosed in 279 children, 10 cases were secondary neoplasms. Age standardized incidence was 16.1 per 100.000 (95% CI 13,6-18,6) for boys and 12.8 per 100.000 (95% CI 10,5-15,0) for girls. There was no significant difference in the incidence rate between the first and second half of the study period. For children aged 0-14 years, the age standardized incidence was 13.6 per 100.000. The incidence was highest in the 0-4 year age group (17.3 per 100.000) and in the 15-17 year age group (19.6 per 100.000). Brain tumors (27.1%) and leukemia (25.0%) were the most common cancer groups diagnosed. Lymphoid leukemia was the most common cancer type (17.9%) and astrocytoma (13.1%) came second. CONCLUSIONS: The incidence of childhood cancer in Iceland is similar to other Western countries. Long-term follow-up is very important in childhood cancer survivors.Inngangur: Krabbamein er n{\ae}st algengasta d{\'a}narors{\"o}k barna {\'a} eftir slysum. Tilgangur rann-s{\'o}knarinnar var a{\dh} kanna n{\'y}gengi krabbameina hj{\'a} b{\"o}rnum {\'a} {\'I}slandi.  A{\dh}fer{\dh}ir: Ranns{\'o}knin var l{\'y}{\dh}grundu{\dh} og n{\'a}{\dh}i til allra <18 {\'a}ra sem greindust me{\dh} krabbamein {\'a} {\'I}slandi fr{\'a} upphafi {\'a}rs 1981 til {\'a}rsloka 2006. Uppl{\'y}singum var safna{\dh} fr{\'a} Krabbameinsskr{\'a} {\'I}slands og {\'u}r sj{\'u}kraskr{\'a}m.  Ni{\dh}urst{\"o}{\dh}ur: Alls greindust 288 krabbameinstilfelli {\'a} t{\'i}mabilinu hj{\'a} 279 b{\"o}rnum. {\'I} 10 tilvikum var um me{\dh}fer{\dh}artengd krabbamein a{\dh} r{\ae}{\dh}a. {\'A}rlegt aldurssta{\dh}la{\dh} n{\'y}gengi hj{\'a} drengjum var 16,1 af 100.000 (95% CI; 13,6-18,6) en hj{\'a} st{\'u}lkum 12,8 af 100.000 (95% CI; 10,5-15,0) en ekki var markt{\ae}kur munur {\'a} n{\'y}gengi milli fyrri og seinni hluta ranns{\'o}knart{\'i}mabilsins. Fyrir aldursbili{\dh} 0-14 {\'a}ra var {\'a}rlegt aldurssta{\dh}la{\dh} n{\'y}gengi 13,6 af 100.000. Mi{\dh}taugakerfis{\ae}xli og hv{\'i}tbl{\ae}{\dh}i voru samanlagt 52,1% allra krabbameinstilvika. Algengasta grein-ingin var br{\'a}{\dh}a eitilfrumuhv{\'i}tbl{\ae}{\dh}i (17,9%) og stjarnfrumna{\ae}xli (13,1%) n{\ae}stalgengust. N{\'y}geng-i{\dh} var h{\ae}st hj{\'a} aldursbilunum 0-4 {\'a}ra (17,3 af 100.00) og 15-17 {\'a}ra (19,6 af 100.000). T{\'i}u b{\"o}rn voru me{\dh} {\th}ekkta me{\dh}f{\ae}dda {\'a}h{\ae}ttu{\th}{\ae}tti.  {\'A}lyktun: N{\'y}gengi krabbameina hj{\'a} b{\"o}rnum {\'a} {\'I}slandi er samb{\ae}rilegt vi{\dh} n{\'a}grannal{\"o}ndin. Mikilv{\ae}gt er a{\dh} fylgja vel eftir b{\"o}rnum sem gengi{\dh} hafa {\'i} gegnum krabbameinsme{\dh}fer{\dh} og {\th}eim sem hafa {\th}ekkta me{\dh}f{\ae}dda {\'a}h{\ae}ttu{\th}{\ae}tti.   ",

keywords = "B{\"o}rn, Krabbamein, Adolescent, Age Distribution, Child, Child, Preschool, Female, Humans, Iceland, Incidence, Infant, Infant, Newborn, Male, Neoplasms, Registries, Sex Distribution, Time Factors, B{\"o}rn, Krabbamein, Adolescent, Age Distribution, Child, Child, Preschool, Female, Humans, Iceland, Incidence, Infant, Infant, Newborn, Male, Neoplasms, Registries, Sex Distribution, Time Factors",

author = "Trausti {\'O}skarsson and J{\'o}nsson, {{\'O}lafur G{\'i}sli} and Kristinsson, {J{\'o}n R.} and J{\'o}nmundsson, {Gu{\dh}mundur K.} and J{\'o}nasson, {J{\'o}n Gunnlaugur} and {\'A}sgeir Haraldsson",

year = "2010",

month = jan,

day = "1",

language = "{\'I}slenska",

journal = "L{\ae}knabla{\dh}i{\dh}",

issn = "0023-7213",

publisher = "Icelandic Medical Association",

}

TY - JOUR

T1 - Krabbamein hjá börnum á Íslandi árin 1981-2006

AU - Óskarsson, Trausti

AU - Jónsson, Ólafur Gísli

AU - Kristinsson, Jón R.

AU - Jónmundsson, Guðmundur K.

AU - Jónasson, Jón Gunnlaugur

AU - Haraldsson, Ásgeir

PY - 2010/1/1

Y1 - 2010/1/1

N2 - BACKGROUND: Childhood cancer is the second most common cause of death in children. The aim of this study was to gather epidemiological information on childhood cancer in Iceland. METHODS: The study was population based and included all children younger than 18 years of age, diagnosed with cancer in Iceland from 1981 to 2006. Information was extracted from the Icelandic Cancer Registry and patient hospital records. RESULTS: During the study period 288 cancer cases were diagnosed in 279 children, 10 cases were secondary neoplasms. Age standardized incidence was 16.1 per 100.000 (95% CI 13,6-18,6) for boys and 12.8 per 100.000 (95% CI 10,5-15,0) for girls. There was no significant difference in the incidence rate between the first and second half of the study period. For children aged 0-14 years, the age standardized incidence was 13.6 per 100.000. The incidence was highest in the 0-4 year age group (17.3 per 100.000) and in the 15-17 year age group (19.6 per 100.000). Brain tumors (27.1%) and leukemia (25.0%) were the most common cancer groups diagnosed. Lymphoid leukemia was the most common cancer type (17.9%) and astrocytoma (13.1%) came second. CONCLUSIONS: The incidence of childhood cancer in Iceland is similar to other Western countries. Long-term follow-up is very important in childhood cancer survivors.Inngangur: Krabbamein er næst algengasta dánarorsök barna á eftir slysum. Tilgangur rann-sóknarinnar var að kanna nýgengi krabbameina hjá börnum á Íslandi.  Aðferðir: Rannsóknin var lýðgrunduð og náði til allra <18 ára sem greindust með krabbamein á Íslandi frá upphafi árs 1981 til ársloka 2006. Upplýsingum var safnað frá Krabbameinsskrá Íslands og úr sjúkraskrám.  Niðurstöður: Alls greindust 288 krabbameinstilfelli á tímabilinu hjá 279 börnum. Í 10 tilvikum var um meðferðartengd krabbamein að ræða. Árlegt aldursstaðlað nýgengi hjá drengjum var 16,1 af 100.000 (95% CI; 13,6-18,6) en hjá stúlkum 12,8 af 100.000 (95% CI; 10,5-15,0) en ekki var marktækur munur á nýgengi milli fyrri og seinni hluta rannsóknartímabilsins. Fyrir aldursbilið 0-14 ára var árlegt aldursstaðlað nýgengi 13,6 af 100.000. Miðtaugakerfisæxli og hvítblæði voru samanlagt 52,1% allra krabbameinstilvika. Algengasta grein-ingin var bráða eitilfrumuhvítblæði (17,9%) og stjarnfrumnaæxli (13,1%) næstalgengust. Nýgeng-ið var hæst hjá aldursbilunum 0-4 ára (17,3 af 100.00) og 15-17 ára (19,6 af 100.000). Tíu börn voru með þekkta meðfædda áhættuþætti.  Ályktun: Nýgengi krabbameina hjá börnum á Íslandi er sambærilegt við nágrannalöndin. Mikilvægt er að fylgja vel eftir börnum sem gengið hafa í gegnum krabbameinsmeðferð og þeim sem hafa þekkta meðfædda áhættuþætti.   

AB - BACKGROUND: Childhood cancer is the second most common cause of death in children. The aim of this study was to gather epidemiological information on childhood cancer in Iceland. METHODS: The study was population based and included all children younger than 18 years of age, diagnosed with cancer in Iceland from 1981 to 2006. Information was extracted from the Icelandic Cancer Registry and patient hospital records. RESULTS: During the study period 288 cancer cases were diagnosed in 279 children, 10 cases were secondary neoplasms. Age standardized incidence was 16.1 per 100.000 (95% CI 13,6-18,6) for boys and 12.8 per 100.000 (95% CI 10,5-15,0) for girls. There was no significant difference in the incidence rate between the first and second half of the study period. For children aged 0-14 years, the age standardized incidence was 13.6 per 100.000. The incidence was highest in the 0-4 year age group (17.3 per 100.000) and in the 15-17 year age group (19.6 per 100.000). Brain tumors (27.1%) and leukemia (25.0%) were the most common cancer groups diagnosed. Lymphoid leukemia was the most common cancer type (17.9%) and astrocytoma (13.1%) came second. CONCLUSIONS: The incidence of childhood cancer in Iceland is similar to other Western countries. Long-term follow-up is very important in childhood cancer survivors.Inngangur: Krabbamein er næst algengasta dánarorsök barna á eftir slysum. Tilgangur rann-sóknarinnar var að kanna nýgengi krabbameina hjá börnum á Íslandi.  Aðferðir: Rannsóknin var lýðgrunduð og náði til allra <18 ára sem greindust með krabbamein á Íslandi frá upphafi árs 1981 til ársloka 2006. Upplýsingum var safnað frá Krabbameinsskrá Íslands og úr sjúkraskrám.  Niðurstöður: Alls greindust 288 krabbameinstilfelli á tímabilinu hjá 279 börnum. Í 10 tilvikum var um meðferðartengd krabbamein að ræða. Árlegt aldursstaðlað nýgengi hjá drengjum var 16,1 af 100.000 (95% CI; 13,6-18,6) en hjá stúlkum 12,8 af 100.000 (95% CI; 10,5-15,0) en ekki var marktækur munur á nýgengi milli fyrri og seinni hluta rannsóknartímabilsins. Fyrir aldursbilið 0-14 ára var árlegt aldursstaðlað nýgengi 13,6 af 100.000. Miðtaugakerfisæxli og hvítblæði voru samanlagt 52,1% allra krabbameinstilvika. Algengasta grein-ingin var bráða eitilfrumuhvítblæði (17,9%) og stjarnfrumnaæxli (13,1%) næstalgengust. Nýgeng-ið var hæst hjá aldursbilunum 0-4 ára (17,3 af 100.00) og 15-17 ára (19,6 af 100.000). Tíu börn voru með þekkta meðfædda áhættuþætti.  Ályktun: Nýgengi krabbameina hjá börnum á Íslandi er sambærilegt við nágrannalöndin. Mikilvægt er að fylgja vel eftir börnum sem gengið hafa í gegnum krabbameinsmeðferð og þeim sem hafa þekkta meðfædda áhættuþætti.   

KW - Börn

KW - Krabbamein

KW - Adolescent

KW - Age Distribution

KW - Child

KW - Child, Preschool

KW - Female

KW - Humans

KW - Iceland

KW - Incidence

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Neoplasms

KW - Registries

KW - Sex Distribution

KW - Time Factors