Instability of chromosomes 1, 3, 16, and 17 in primary breast carcinomas inferred by fluorescence in situ hybridization

Kesara Anamthawat-Jónsson; Jórunn E. Eyfjörd; Helga M. Ögmundsdöttir; Ingibjörg Pétursdóttir; Margrét Steinarsdóttir

doi:10.1016/0165-4608(95)00203-0

Instability of chromosomes 1, 3, 16, and 17 in primary breast carcinomas inferred by fluorescence in situ hybridization

Kesara Anamthawat-Jónsson^*, Jórunn E. Eyfjörd, Helga M. Ögmundsdöttir, Ingibjörg Pétursdóttir, Margrét Steinarsdóttir

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Abnormalities of chromosomes 1, 3, 16, and 17 were examined in 203 metaphase cells from 12 cases of primary breast carcinoma using fluorescence in situ hybridization with chromosome painting probes. The most common structural abnormalities were chromosomal rearrangements, especially translocations, and chromosome 17 was most frequently involved in these types of changes. Chromosome 16 was preferentially involved in the losses and deletions, while chromosomes 1 and 17 were more involved in the gains, including amplifications, than other chromosomes. This approach has revealed a different profile of abnormalities from those normally shown by G-handing analysis. Some of these changes are likely to be novel and may be of biologic or clinical importance in breast cancer.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Cancer Genetics and Cytogenetics
Volume	88
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(95)00203-0
Publication status	Published - May 1996

Bibliographical note

Funding Information:
This work was supported by the Icelandic Council of Science. We thank Professor Bruce Ponder for the chromosome 17 painting probe used during the preparation of the present study.

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10.1016/0165-4608(95)00203-0

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title = "Instability of chromosomes 1, 3, 16, and 17 in primary breast carcinomas inferred by fluorescence in situ hybridization",

abstract = "Abnormalities of chromosomes 1, 3, 16, and 17 were examined in 203 metaphase cells from 12 cases of primary breast carcinoma using fluorescence in situ hybridization with chromosome painting probes. The most common structural abnormalities were chromosomal rearrangements, especially translocations, and chromosome 17 was most frequently involved in these types of changes. Chromosome 16 was preferentially involved in the losses and deletions, while chromosomes 1 and 17 were more involved in the gains, including amplifications, than other chromosomes. This approach has revealed a different profile of abnormalities from those normally shown by G-handing analysis. Some of these changes are likely to be novel and may be of biologic or clinical importance in breast cancer.",

author = "Kesara Anamthawat-J{\'o}nsson and Eyfj{\"o}rd, {J{\'o}runn E.} and {\"O}gmundsd{\"o}ttir, {Helga M.} and Ingibj{\"o}rg P{\'e}tursd{\'o}ttir and Margr{\'e}t Steinarsd{\'o}ttir",

note = "Funding Information: This work was supported by the Icelandic Council of Science. We thank Professor Bruce Ponder for the chromosome 17 painting probe used during the preparation of the present study.",

year = "1996",

month = may,

doi = "10.1016/0165-4608(95)00203-0",

language = "English",

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T1 - Instability of chromosomes 1, 3, 16, and 17 in primary breast carcinomas inferred by fluorescence in situ hybridization

AU - Anamthawat-Jónsson, Kesara

AU - Eyfjörd, Jórunn E.

AU - Ögmundsdöttir, Helga M.

AU - Pétursdóttir, Ingibjörg

AU - Steinarsdóttir, Margrét

N1 - Funding Information: This work was supported by the Icelandic Council of Science. We thank Professor Bruce Ponder for the chromosome 17 painting probe used during the preparation of the present study.

PY - 1996/5

Y1 - 1996/5

N2 - Abnormalities of chromosomes 1, 3, 16, and 17 were examined in 203 metaphase cells from 12 cases of primary breast carcinoma using fluorescence in situ hybridization with chromosome painting probes. The most common structural abnormalities were chromosomal rearrangements, especially translocations, and chromosome 17 was most frequently involved in these types of changes. Chromosome 16 was preferentially involved in the losses and deletions, while chromosomes 1 and 17 were more involved in the gains, including amplifications, than other chromosomes. This approach has revealed a different profile of abnormalities from those normally shown by G-handing analysis. Some of these changes are likely to be novel and may be of biologic or clinical importance in breast cancer.

AB - Abnormalities of chromosomes 1, 3, 16, and 17 were examined in 203 metaphase cells from 12 cases of primary breast carcinoma using fluorescence in situ hybridization with chromosome painting probes. The most common structural abnormalities were chromosomal rearrangements, especially translocations, and chromosome 17 was most frequently involved in these types of changes. Chromosome 16 was preferentially involved in the losses and deletions, while chromosomes 1 and 17 were more involved in the gains, including amplifications, than other chromosomes. This approach has revealed a different profile of abnormalities from those normally shown by G-handing analysis. Some of these changes are likely to be novel and may be of biologic or clinical importance in breast cancer.

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IS - 1

ER -

Instability of chromosomes 1, 3, 16, and 17 in primary breast carcinomas inferred by fluorescence in situ hybridization

Abstract

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