Improving topical treatments for skin diseases

Hekla Sigmundsdottir

Research output: Contribution to journalArticlepeer-review


Skin diseases and skin problems affect millions of people every day. Skin lesions are often difficult to treat locally and much is to be gained by developing more targeted treatments to avoid the use of systemic immunosuppressant drugs. Recent data on the function of microenvironmental factors could help improve such therapies. Vitamins A and D and their metabolites have strong effects on both innate and adaptive immune responses, and can suppress inflammation, lymphocyte infiltration and function, as well as the ability to increase regulatory tasks within the skin. Combinatorial therapy that includes these metabolites, cytokines, chemokines or other agents could help to alter the local microenvironment and sway immune responses as needed, depending on the origin of the skin inflammation. Here, I argue that microenvironmental factors might be used to improve topical treatments in chronic inflammatory skin diseases such as psoriasis and atopic dermatitis, where T cells play a pathogenic role.
Original languageEnglish
JournalTrends in Pharmacological Sciences
Publication statusPublished - Jun 2010

Other keywords

  • Administration, Topical
  • Animals
  • Dendritic Cells
  • Dermatitis
  • Dermatologic Agents
  • Drug Delivery Systems
  • Humans
  • Immunologic Factors
  • Models, Immunological
  • Skin
  • Skin Diseases
  • T-Lymphocytes


Dive into the research topics of 'Improving topical treatments for skin diseases'. Together they form a unique fingerprint.

Cite this