Immunoglobulin class and subclass concentrations after treatment of childhood leukemia

Valur Helgi Kristinsson, J. R. Kristinsson, Gudmundur K. Jonmundsson, Olafur G. Jonsson, Arni V. Thorsson, Asgeir Haraldsson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

With greatly increased survival rates after childhood leukemia during the last 3 decades, the long-term effects of the treatment have become more evident. The disease and its treatment impair the immune system, but the duration of this impairment is unknown. The authors studied the serum concentrations of immunoglobulins and IgG subclasses in 20 Icelandic children cured of leukemia on average 8 years and 3 months after their treatment ended. Although no marked deviations were found in the concentrations of the main immunoglobulin classes IgA, IgM, IgG, and IgE, the IgG subclass levels were below reference values. The patients had on average 0.9 of age standardized reference values of IgG1, 0.5 of IgG2, 0.8 of IgG3, and O. 7 of IgG4. However, none had any autoimmune diseases or a markedly increased tendency for infections. The results indicate that although the immunoglobulin classes regain their normal values within a few years after cessation of treatment, recovery of the IgG subclasses, especially IgG2, is impaired.

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalPediatric Hematology and Oncology
Volume18
Issue number3
DOIs
Publication statusPublished - 2001

Bibliographical note

Funding Information:
Riveed 10cAuegust 20; accepte00d 20 Septere20m. 00b We thnk Gilliaan Holt and Erla MarÂõ a Kristinsdo tirtfor thir assistance e during the st. Thue sduty yd was supported by a grant from the Icelandic Childhood Cancer Parent Organization. Addrssecorrpeondesne tocProf. Asgeir Haraldsson, MD, PhD, Department ofPadaericsit, University Hospita,10l1ReykjavÂõ k,Iceland.E-ma:asgieli@rsp.ir s

Other keywords

  • Child
  • Drug therapy
  • Immunoglobulins
  • Leukemia

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