Highly increased familial risks for specific lymphoma subtypes

Lynn R. Goldin; Magnus Björkholm; Sigurdur Y. Kristinsson; Ingemar Turesson; Ola Landgren

doi:10.1111/j.1365-2141.2009.07721.x

Highly increased familial risks for specific lymphoma subtypes

Lynn R. Goldin, Magnus Björkholm, Sigurdur Y. Kristinsson, Ingemar Turesson, Ola Landgren

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

Studies have shown that familial risk contributes to aetiology of lymphomas. Using large population registries from Sweden, we evaluated risk of lymphoma subtypes among first-degree relatives of 2668 follicular lymphoma (FL) patients, 2517 diffuse large B-cell lymphoma (DLBCL) patients, and 6963 Hodgkin lymphoma (HL) patients compared to first-degree relatives of controls. Relatives were at the highest risk for developing the same lymphoma subtype as the case. DLBCL was increased 10-fold among relatives of DLBCL patients, FL was increased fourfold among relatives of FL patients and HL was increased fourfold among relatives of HL patients. These results imply that germline susceptibility genes are specific to lymphoma subtype.

Original language	English
Pages (from-to)	91-94
Number of pages	4
Journal	British Journal of Haematology
Volume	146
Issue number	1
DOIs	https://doi.org/10.1111/j.1365-2141.2009.07721.x
Publication status	Published - Jul 2009

Other keywords

Diffuse large B-cell lymphoma
Familial risk
Follicular lymphoma
Hodgkin lymphoma
Non-Hodgkin lymphoma

Access to Document

10.1111/j.1365-2141.2009.07721.x

Cite this

@article{c677721ad1c04f3480d8e50119d8ee3e,

title = "Highly increased familial risks for specific lymphoma subtypes",

abstract = "Studies have shown that familial risk contributes to aetiology of lymphomas. Using large population registries from Sweden, we evaluated risk of lymphoma subtypes among first-degree relatives of 2668 follicular lymphoma (FL) patients, 2517 diffuse large B-cell lymphoma (DLBCL) patients, and 6963 Hodgkin lymphoma (HL) patients compared to first-degree relatives of controls. Relatives were at the highest risk for developing the same lymphoma subtype as the case. DLBCL was increased 10-fold among relatives of DLBCL patients, FL was increased fourfold among relatives of FL patients and HL was increased fourfold among relatives of HL patients. These results imply that germline susceptibility genes are specific to lymphoma subtype.",

keywords = "Diffuse large B-cell lymphoma, Familial risk, Follicular lymphoma, Hodgkin lymphoma, Non-Hodgkin lymphoma",

author = "Goldin, {Lynn R.} and Magnus Bj{\"o}rkholm and Kristinsson, {Sigurdur Y.} and Ingemar Turesson and Ola Landgren",

year = "2009",

month = jul,

doi = "10.1111/j.1365-2141.2009.07721.x",

language = "English",

volume = "146",

pages = "91--94",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "1",

}

TY - JOUR

T1 - Highly increased familial risks for specific lymphoma subtypes

AU - Goldin, Lynn R.

AU - Björkholm, Magnus

AU - Kristinsson, Sigurdur Y.

AU - Turesson, Ingemar

AU - Landgren, Ola

PY - 2009/7

Y1 - 2009/7

N2 - Studies have shown that familial risk contributes to aetiology of lymphomas. Using large population registries from Sweden, we evaluated risk of lymphoma subtypes among first-degree relatives of 2668 follicular lymphoma (FL) patients, 2517 diffuse large B-cell lymphoma (DLBCL) patients, and 6963 Hodgkin lymphoma (HL) patients compared to first-degree relatives of controls. Relatives were at the highest risk for developing the same lymphoma subtype as the case. DLBCL was increased 10-fold among relatives of DLBCL patients, FL was increased fourfold among relatives of FL patients and HL was increased fourfold among relatives of HL patients. These results imply that germline susceptibility genes are specific to lymphoma subtype.

AB - Studies have shown that familial risk contributes to aetiology of lymphomas. Using large population registries from Sweden, we evaluated risk of lymphoma subtypes among first-degree relatives of 2668 follicular lymphoma (FL) patients, 2517 diffuse large B-cell lymphoma (DLBCL) patients, and 6963 Hodgkin lymphoma (HL) patients compared to first-degree relatives of controls. Relatives were at the highest risk for developing the same lymphoma subtype as the case. DLBCL was increased 10-fold among relatives of DLBCL patients, FL was increased fourfold among relatives of FL patients and HL was increased fourfold among relatives of HL patients. These results imply that germline susceptibility genes are specific to lymphoma subtype.

KW - Diffuse large B-cell lymphoma

KW - Familial risk

KW - Follicular lymphoma

KW - Hodgkin lymphoma

KW - Non-Hodgkin lymphoma

UR - http://www.scopus.com/inward/record.url?scp=66949164763&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2141.2009.07721.x

DO - 10.1111/j.1365-2141.2009.07721.x

M3 - Article

C2 - 19438470

AN - SCOPUS:66949164763

SN - 0007-1048

VL - 146

SP - 91

EP - 94

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 1

ER -

Highly increased familial risks for specific lymphoma subtypes

Abstract

Other keywords

Access to Document

Fingerprint

Cite this