HaNDL - Viktig men gåtfull differential-diagnos med svår migränliknande huvudvärk: Förknippat med neurologiska symtom och lymfocytär pleocytos

Translated title of the contribution: HaNDL (syndrome of transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis)

Malin Säflund, Christina Sjöstrand, Olafur Sveinsson

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The syndrome of transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis (HaNDL) is a self-limited disorder with an unknown pathogenesis, characterized by one or more transient episodes of severe headache accompanied with neurologic deficits, and lymphocytic pleocytosis in the cerebrospinal fluid (CSF). Despite being uncommon and benign it is important for clinicians to identify and differentiate HaNDL from other potentially fatal neurologic disorders. We present six HaNDL patients from our institution. All had a relatively typical course with repeated migrainelike headaches accompanied by various transient neurologic deficits and a mean CSF lymphocytic pleocytosis of 178 cells/mm3. Most of the patients were disorientated during the attacks, which has been described previously. When neurofilament light in CSF was measured, there was a substantial increase of this marker which normalized after several months, suggesting certain nerve damage.

Translated title of the contributionHaNDL (syndrome of transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis)
Original languageSwedish
Pages (from-to)422
Number of pages1
JournalLakartidningen
Volume115
Issue number9-10
Publication statusPublished - 2018

Bibliographical note

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© 2018, Swedish Medical Association. All rights reserved.

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