Glomerular filtration rate after a 12-wk resistance exercise program with post-exercise protein ingestion in community dwelling elderly

Alfons Ramel*, Atli Arnarson, Olof G. Geirsdottir, Palmi V. Jonsson, Inga Thorsdottir

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Objective: Increased protein intake and resistance exercise can be beneficial for maintenance of lean body mass (LBM) in older adults. However, these factors could also negatively affect renal function. We investigated changes in renal function after a 12-wk resistance exercise program combined with protein supplementation in community dwelling older adults. Methods: Patients (N = 237, 73.7 ± 5.7 y, 58.2% female) participated in a 12-wk resistance exercise program (3 times/wk) designed to increase strength and muscle mass of major muscle groups. Participants were randomly assigned to one of three dietary supplements consumed directly after training: whey protein drink (20 g whey protein, 20 g carbohydrates), milk protein drink (20 g milk protein, 20 g carbohydrates), or carbohydrate drink (40 g carbohydrates). Renal function was estimated as glomerular filtration rate (GFR, Cockcroft-Gault formula), and dietary intake was measured as 3-d-weighed food record at baseline and endpoint. Results: During the intervention, energy intake did not increase. Carbohydrate intake increased in the carbohydrate group and protein intake increased in the milk group, both approximately in accordance with the supplementation. In the whey group, protein intake did not increase, but carbohydrate intake did. GFR increased after the intervention (+4.4 mL/min/1.73 m2; P < 0.001), and the changes were similar in men and women or in the age quartiles. Changes in GFR at endpoint were not associated with LBM, dietary supplements, or total protein intake. Conclusions: A 12-wk resistance exercise program combined with protein supplementation in community dwelling older adults does not negatively affect GFR. The supplementation had only minor effects on total dietary intake.

Original languageEnglish
Pages (from-to)719-723
Number of pages5
JournalNutrition
Volume29
Issue number5
DOIs
Publication statusPublished - May 2013

Bibliographical note

Funding Information:
This study was part of the IceProQualita project, which was funded by the Icelandic Technology Development Fund (No 071323008 ), Research Fund of the University of Iceland, a grant from Landspitali University Hospital Research Fund, and the Helga Jonsdottir and Sigurlidi Kristjansson Geriatric Research Fund . This study does not necessary reflect the views of the sponsors and in no way anticipates sponsors' future policy in this area. The trial is registered at the US National Library of Medicine (Nr. NCT01074879 ).

Other keywords

  • Cockcroft-Gault formula
  • Glomerular filtration rate
  • Old adults
  • Strength
  • Whey protein

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