Genome-scale models and the genetic basis for E. coli adaptation

M. Kenyon Applebee, Bernhard Palsson*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


In this chapter we describe work stemming from the development of a stoichiometrically-constrained model of Escherichia coli metabolism, to experimental evolution of strains, to the analysis of the function of acquired adaptive mutations with the goal of understanding their system-wide effect on phenotype.

Original languageEnglish
Title of host publicationSystems Biology and Biotechnology of Escherichia coli
PublisherSpringer Netherlands
Number of pages20
ISBN (Print)9781402093937
Publication statusPublished - 2009


Dive into the research topics of 'Genome-scale models and the genetic basis for E. coli adaptation'. Together they form a unique fingerprint.

Cite this