Genetic analysis of the contribution of IL10 to systemic lupus erythematosus

Marta E. Alarcón-Riquelme; Anna Karin B. Lindqvist; Inger Jonasson; Bo Johanneson; Sayonara Sandino; Jorge Alcocer-Varela; Julio Granados; Helga Kristjánsdóttir; Gerdur Gröndal; Elisabet Svenungsson; Ingrid Lundberg; Kristján Steinsson; Lars Klareskog; Gunnar Sturfelt; Lennart Truedsson; Donato Alarcón-Segovia; Ulf B. Gyllensten

Genetic analysis of the contribution of IL10 to systemic lupus erythematosus

Marta E. Alarcón-Riquelme^*, Anna Karin B. Lindqvist, Inger Jonasson, Bo Johanneson, Sayonara Sandino, Jorge Alcocer-Varela, Julio Granados, Helga Kristjánsdóttir, Gerdur Gröndal, Elisabet Svenungsson, Ingrid Lundberg, Kristján Steinsson, Lars Klareskog, Gunnar Sturfelt, Lennart Truedsson, Donato Alarcón-Segovia, Ulf B. Gyllensten

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Objective. To study the contribution of the IL10 gene to the susceptibility to systemic lupus erythematosus (SLE). Methods. Analysis by fluorescent-semiautomated genotyping of a dinucleotide repeat located in the promoter region of the IL10 locus (microsatellite G). Results. No significant difference was found in the frequencies of the microsatellite alleles of 330 Mexican patients with SLE compared to 368 controls from the same population. Two-point linkage analyses were carried out using 13 Mexican, 13 Swedish, and 8 Icelandic families with 2 or more cases with SLE. No linkage was revealed between IL10 and SLE, using a variety of parameter settings. Conclusion. Our results do not support that the IL10 gene contributes to the susceptibility to SLE in the populations we studied.

Original language	English
Pages (from-to)	2148-2152
Number of pages	5
Journal	Journal of Rheumatology
Volume	26
Issue number	10
Publication status	Published - 1999

Other keywords

Genetics
Interleukin 10
Systemic lupus erythematosus

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Alarcón-Riquelme, M. E., Lindqvist, A. K. B., Jonasson, I., Johanneson, B., Sandino, S., Alcocer-Varela, J., Granados, J., Kristjánsdóttir, H., Gröndal, G., Svenungsson, E., Lundberg, I., Steinsson, K., Klareskog, L., Sturfelt, G., Truedsson, L., Alarcón-Segovia, D., & Gyllensten, U. B. (1999). Genetic analysis of the contribution of IL10 to systemic lupus erythematosus. Journal of Rheumatology, 26(10), 2148-2152.

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title = "Genetic analysis of the contribution of IL10 to systemic lupus erythematosus",

abstract = "Objective. To study the contribution of the IL10 gene to the susceptibility to systemic lupus erythematosus (SLE). Methods. Analysis by fluorescent-semiautomated genotyping of a dinucleotide repeat located in the promoter region of the IL10 locus (microsatellite G). Results. No significant difference was found in the frequencies of the microsatellite alleles of 330 Mexican patients with SLE compared to 368 controls from the same population. Two-point linkage analyses were carried out using 13 Mexican, 13 Swedish, and 8 Icelandic families with 2 or more cases with SLE. No linkage was revealed between IL10 and SLE, using a variety of parameter settings. Conclusion. Our results do not support that the IL10 gene contributes to the susceptibility to SLE in the populations we studied.",

keywords = "Genetics, Interleukin 10, Systemic lupus erythematosus",

author = "Alarc{\'o}n-Riquelme, {Marta E.} and Lindqvist, {Anna Karin B.} and Inger Jonasson and Bo Johanneson and Sayonara Sandino and Jorge Alcocer-Varela and Julio Granados and Helga Kristj{\'a}nsd{\'o}ttir and Gerdur Gr{\"o}ndal and Elisabet Svenungsson and Ingrid Lundberg and Kristj{\'a}n Steinsson and Lars Klareskog and Gunnar Sturfelt and Lennart Truedsson and Donato Alarc{\'o}n-Segovia and Gyllensten, {Ulf B.}",

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Alarcón-Riquelme, ME, Lindqvist, AKB, Jonasson, I, Johanneson, B, Sandino, S, Alcocer-Varela, J, Granados, J, Kristjánsdóttir, H, Gröndal, G, Svenungsson, E, Lundberg, I, Steinsson, K, Klareskog, L, Sturfelt, G, Truedsson, L, Alarcón-Segovia, D & Gyllensten, UB 1999, 'Genetic analysis of the contribution of IL10 to systemic lupus erythematosus', Journal of Rheumatology, vol. 26, no. 10, pp. 2148-2152.

TY - JOUR

T1 - Genetic analysis of the contribution of IL10 to systemic lupus erythematosus

AU - Alarcón-Riquelme, Marta E.

AU - Lindqvist, Anna Karin B.

AU - Jonasson, Inger

AU - Johanneson, Bo

AU - Sandino, Sayonara

AU - Alcocer-Varela, Jorge

AU - Granados, Julio

AU - Kristjánsdóttir, Helga

AU - Gröndal, Gerdur

AU - Svenungsson, Elisabet

AU - Lundberg, Ingrid

AU - Steinsson, Kristján

AU - Klareskog, Lars

AU - Sturfelt, Gunnar

AU - Truedsson, Lennart

AU - Alarcón-Segovia, Donato

AU - Gyllensten, Ulf B.

PY - 1999

Y1 - 1999

N2 - Objective. To study the contribution of the IL10 gene to the susceptibility to systemic lupus erythematosus (SLE). Methods. Analysis by fluorescent-semiautomated genotyping of a dinucleotide repeat located in the promoter region of the IL10 locus (microsatellite G). Results. No significant difference was found in the frequencies of the microsatellite alleles of 330 Mexican patients with SLE compared to 368 controls from the same population. Two-point linkage analyses were carried out using 13 Mexican, 13 Swedish, and 8 Icelandic families with 2 or more cases with SLE. No linkage was revealed between IL10 and SLE, using a variety of parameter settings. Conclusion. Our results do not support that the IL10 gene contributes to the susceptibility to SLE in the populations we studied.

AB - Objective. To study the contribution of the IL10 gene to the susceptibility to systemic lupus erythematosus (SLE). Methods. Analysis by fluorescent-semiautomated genotyping of a dinucleotide repeat located in the promoter region of the IL10 locus (microsatellite G). Results. No significant difference was found in the frequencies of the microsatellite alleles of 330 Mexican patients with SLE compared to 368 controls from the same population. Two-point linkage analyses were carried out using 13 Mexican, 13 Swedish, and 8 Icelandic families with 2 or more cases with SLE. No linkage was revealed between IL10 and SLE, using a variety of parameter settings. Conclusion. Our results do not support that the IL10 gene contributes to the susceptibility to SLE in the populations we studied.

KW - Genetics

KW - Interleukin 10

KW - Systemic lupus erythematosus

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M3 - Article

C2 - 10529131

AN - SCOPUS:0344549394

SN - 0315-162X

VL - 26

SP - 2148

EP - 2152

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 10

ER -

Genetic analysis of the contribution of IL10 to systemic lupus erythematosus

Abstract

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