Further studies on serrated neoplasias of the cardia: A review and case report

Carlos A. Rubio*, Fredrik Petersson, Anders Höög, Jon G. Jónasson, Gabriella Nesi, Evangelos Chandanos, Mats Lindblad

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


We have previously recorded 6 cases of serrated adenoma in the cardia. Here we report a case, which differed cytologically from the 6 preceding cases in as much as the adenomatous cells had clear, micro-vacuolated cytoplasm and secreted neutral mucins. Similar cellular features found in gastric carcinomas were classified by Mulligan as of pylorocardiac gland cell type. Six of the 7 cases (including the one reported here) showed areas of invasive carcinoma. Because of its location, histological and histochemical features, the reported neoplasia was called serrated adenoma malignum of the cardia (Mulligan type). Serrated adenomas of the cardia seem to have a particular proclivity to evolve into invasive carcinomas.

Original languageEnglish
Pages (from-to)4431-4434
Number of pages4
JournalAnticancer Research
Issue number6 C
Publication statusPublished - Nov 2007

Other keywords

  • Gastric
  • Neoplasia
  • Pylorocardiac type
  • Serrated


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