Fungal phospholipase activity and susceptibility to lipid preparations of amphotericin B

M. Gottfredsson; C. J. Jessup; G. M. Cox; J. R. Perfect; M. A. Ghannoum

doi:10.1128/AAC.45.11.3231-3233.2001

Fungal phospholipase activity and susceptibility to lipid preparations of amphotericin B

M. Gottfredsson, C. J. Jessup, G. M. Cox^*, J. R. Perfect, M. A. Ghannoum

^*Corresponding author for this work

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9 Citations (Scopus)

Abstract

It has been postulated that phospholipases of fungal origin can affect in vitro susceptibility testing of amphotericin B lipid complex (ABLC). We used specific phospholipase-deficient mutants of Candida albicans and Cryptococcus neoformans in susceptibility testing and demonstrated that extracellular fungal phospholipase activity does not influence the in vitro susceptibilities of these two fungi to ABLC.

Original language	English
Pages (from-to)	3231-3233
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	45
Issue number	11
DOIs	https://doi.org/10.1128/AAC.45.11.3231-3233.2001
Publication status	Published - 2001

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10.1128/AAC.45.11.3231-3233.2001

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title = "Fungal phospholipase activity and susceptibility to lipid preparations of amphotericin B",

abstract = "It has been postulated that phospholipases of fungal origin can affect in vitro susceptibility testing of amphotericin B lipid complex (ABLC). We used specific phospholipase-deficient mutants of Candida albicans and Cryptococcus neoformans in susceptibility testing and demonstrated that extracellular fungal phospholipase activity does not influence the in vitro susceptibilities of these two fungi to ABLC.",

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AU - Cox, G. M.

AU - Perfect, J. R.

AU - Ghannoum, M. A.

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AB - It has been postulated that phospholipases of fungal origin can affect in vitro susceptibility testing of amphotericin B lipid complex (ABLC). We used specific phospholipase-deficient mutants of Candida albicans and Cryptococcus neoformans in susceptibility testing and demonstrated that extracellular fungal phospholipase activity does not influence the in vitro susceptibilities of these two fungi to ABLC.

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U2 - 10.1128/AAC.45.11.3231-3233.2001

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ER -

Fungal phospholipase activity and susceptibility to lipid preparations of amphotericin B

Abstract

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