Extracellular calcium protects isolated rat hepatocytes from injury

Marc W. Fariss*, Kristin Olafsdottir, Donald J. Reed

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)


The incubation of isolated rat hepatocytes in calcium-free medium resulted in a pronounced increase in lipid peroxidation, mitochondrial and cytoplasmic glutathione depletion, glutathione disulfide formation and efflux of reduced gluathione as compared with hepatocytes incubated in calcium containing medium. These data suggest that extracellular calcium ions serve a protective role in isolated rat hepatocytes against cell injury.

Original languageEnglish
Pages (from-to)102-110
Number of pages9
JournalBiochemical and Biophysical Research Communications
Issue number1
Publication statusPublished - 31 May 1984


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