Evidence for the Introduction of a Multiresistant Clone of Serotype 6B Streptococcus pneumoniae from Spain to Iceland in the Late 1980s

Alexander Tomasz, Sonia Soares, Karl G. Kristinsson, James M. Musser, Alexander Tomasz, Sonia Soares, Karl G. Kristinsson, James M. Musser, Alexander Tomasz, Sonia Soares, Karl G. Kristinsson, James M. Musser

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290 Citations (Scopus)

Abstract

Almost all of the multiresistant pneumococci that appeared suddenly in clinical specimens in Iceland between 1989 and 1992 belonged to serogroup 6. Fifty-seven of these isolates were analyzed for serotype, penicillin-binding protein pattern, multilocus enzyme genotype, and fragmentation pattern obtained by pulsed-field electrophoretic separation of restriction enzyme digests of chromosomal DNA. All isolates were of serotype 6B and had similar or identical patterns in each molecular test. The Icelandic isolates were indistinguishable from a subgroup of multiresistant serotype 6B pneumococci that has been present with high incidence in Spain during the past two decades. The data suggest the import to Iceland of a single multiresistant clone of pneumococcus, most likely from Spain.

Original languageEnglish
Pages (from-to)158-163
Number of pages6
JournalJournal of Infectious Diseases
Volume168
Issue number1
DOIs
Publication statusPublished - Jul 1993

Bibliographical note

Funding Information:
Received 25 August 1992; revised 8 March 1993. Grant support: National Institutes of Health, AI-16794 (to A.T.) and AI-33119 (to J.M.M.), and University of Iceland Research Fund. Reprints or correspondence: Dr. Alexander Tornasz, Rockefeller University, Laboratory of Microbiology. 1230 York Ave .. New York. NY 10021.

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