Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: A Danish genome-wide association study

DBDS Genomic Consortium

doi:10.1016/j.jbspin.2022.105357

Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: A Danish genome-wide association study

DBDS Genomic Consortium

Research output: Contribution to journal › Letter › peer-review

Original language	English
Article number	105357
Pages (from-to)	105357
Journal	Joint Bone Spine
Volume	89
Issue number	4
DOIs	https://doi.org/10.1016/j.jbspin.2022.105357
Publication status	Published - 1 Feb 2022

Bibliographical note

Funding Information:
Supported by grants from the Danish Rheumatism Association (non-commercial) to HCB Leffers (A5094) and S Jacobsen (A3865). D Westergaard, S Brunak and K Banasik were supported by grants from the Novo Nordisk Foundation (NNF17OC0027594, NNF14CC0001, and NNF18SA0034956).

Funding Information:
The authors would like to thank all the SLE patients participating in the project. The authors would like to thank the national The Danish Rheumatologic Database (DANBIO), Denmark. The authors would also like to thank the Danish Rheumatologic Biobank (DRB). The authors would also like to thank the Danish Blood Donor Study (DBDS).

Other keywords

Clinical phenotype
Disease manifestations
Genome wide association study
GWAS
Lupus Nephritis
SLE
Systemic Lupus Erythematosus
NADPH Oxidases
Genetic Predisposition to Disease
Genome-Wide Association Study
beta Karyopherins
Humans
CD11b Antigen/genetics
Lupus Erythematosus, Systemic/genetics
Case-Control Studies
Denmark/epidemiology
Interferon Regulatory Factors/genetics
STAT4 Transcription Factor
Polymorphism, Single Nucleotide

Access to Document

10.1016/j.jbspin.2022.105357

Cite this

@article{f4c2a289e5594bcb910aab5e2d4933fd,

title = "Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: A Danish genome-wide association study",

keywords = "Clinical phenotype, Disease manifestations, Genome wide association study, GWAS, Lupus Nephritis, SLE, Systemic Lupus Erythematosus, NADPH Oxidases, Genetic Predisposition to Disease, Genome-Wide Association Study, beta Karyopherins, Humans, CD11b Antigen/genetics, Lupus Erythematosus, Systemic/genetics, Case-Control Studies, Denmark/epidemiology, Interferon Regulatory Factors/genetics, STAT4 Transcription Factor, Polymorphism, Single Nucleotide",

author = "{DBDS Genomic Consortium} and Leffers, {Henrik Christian Bidstrup} and David Westergaard and Saedis Saevarsdottir and Ingileif Jonsdottir and Pedersen, {Ole Birger} and Anne Troldborg and Anne Voss and Salome Kristensen and Jesper Lindhardsen and Prabhat Kumar and Asta Linauskas and Lars Juul and Krogh, {Niels Steen} and Bent Deleuran and Lene Dreyer and Michael Schwinn and Th{\o}rner, {Lise Wegner} and Lotte Hindhede and Christian Erikstrup and Henrik Ullum and S{\o}ren Brunak and Kari Stefansson and Karina Banasik and S{\o}ren Jacobsen",

note = "Funding Information: Supported by grants from the Danish Rheumatism Association (non-commercial) to HCB Leffers (A5094) and S Jacobsen (A3865). D Westergaard, S Brunak and K Banasik were supported by grants from the Novo Nordisk Foundation (NNF17OC0027594, NNF14CC0001, and NNF18SA0034956). Funding Information: The authors would like to thank all the SLE patients participating in the project. The authors would like to thank the national The Danish Rheumatologic Database (DANBIO), Denmark. The authors would also like to thank the Danish Rheumatologic Biobank (DRB). The authors would also like to thank the Danish Blood Donor Study (DBDS).",

year = "2022",

month = feb,

day = "1",

doi = "10.1016/j.jbspin.2022.105357",

language = "English",

volume = "89",

pages = "105357",

journal = "Joint Bone Spine",

issn = "1297-319X",

publisher = "Elsevier Masson",

number = "4",

}

TY - JOUR

T1 - Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations

T2 - A Danish genome-wide association study

AU - DBDS Genomic Consortium

AU - Leffers, Henrik Christian Bidstrup

AU - Westergaard, David

AU - Saevarsdottir, Saedis

AU - Jonsdottir, Ingileif

AU - Pedersen, Ole Birger

AU - Troldborg, Anne

AU - Voss, Anne

AU - Kristensen, Salome

AU - Lindhardsen, Jesper

AU - Kumar, Prabhat

AU - Linauskas, Asta

AU - Juul, Lars

AU - Krogh, Niels Steen

AU - Deleuran, Bent

AU - Dreyer, Lene

AU - Schwinn, Michael

AU - Thørner, Lise Wegner

AU - Hindhede, Lotte

AU - Erikstrup, Christian

AU - Ullum, Henrik

AU - Brunak, Søren

AU - Stefansson, Kari

AU - Banasik, Karina

AU - Jacobsen, Søren

N1 - Funding Information: Supported by grants from the Danish Rheumatism Association (non-commercial) to HCB Leffers (A5094) and S Jacobsen (A3865). D Westergaard, S Brunak and K Banasik were supported by grants from the Novo Nordisk Foundation (NNF17OC0027594, NNF14CC0001, and NNF18SA0034956). Funding Information: The authors would like to thank all the SLE patients participating in the project. The authors would like to thank the national The Danish Rheumatologic Database (DANBIO), Denmark. The authors would also like to thank the Danish Rheumatologic Biobank (DRB). The authors would also like to thank the Danish Blood Donor Study (DBDS).

PY - 2022/2/1

Y1 - 2022/2/1

KW - Clinical phenotype

KW - Disease manifestations

KW - Genome wide association study

KW - GWAS

KW - Lupus Nephritis

KW - SLE

KW - Systemic Lupus Erythematosus

KW - NADPH Oxidases

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - beta Karyopherins

KW - Humans

KW - CD11b Antigen/genetics

KW - Lupus Erythematosus, Systemic/genetics

KW - Case-Control Studies

KW - Denmark/epidemiology

KW - Interferon Regulatory Factors/genetics

KW - STAT4 Transcription Factor

KW - Polymorphism, Single Nucleotide

UR - http://www.scopus.com/inward/record.url?scp=85125522423&partnerID=8YFLogxK

U2 - 10.1016/j.jbspin.2022.105357

DO - 10.1016/j.jbspin.2022.105357

M3 - Letter

C2 - 35167971

AN - SCOPUS:85125522423

SN - 1297-319X

VL - 89

SP - 105357

JO - Joint Bone Spine

JF - Joint Bone Spine

IS - 4

M1 - 105357

ER -