Endocrine regulation of ion transport in the avian lower intestine

Gary Laverty*, Vibeke S. Elbrønd, Sighvatur S. Árnason, Erik Skadhauge

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)

Abstract

The lower intestine (colon and coprodeum) of the domestic fowl maintains a very active, transporting epithelium, with a microvillus brush border, columnar epithelial cells, and a variety of transport systems. The colon of normal or high salt-acclimated hens expresses sodium-linked glucose and amino acid cotransporters, while the coprodeum is relatively inactive. Following acclimation to low salt diets, however, both colon and coprodeum shift to a pattern of high expression of electrogenic sodium channels, and the colonic cotransporter activity is simultaneously downregulated. These changes in the transport patterns seem to be regulated, at least in part, by aldosterone. Our recent work with this tissue has focused on whether aldosterone alone can account for the low salt pattern of transport. Other work has looked at the changes in morphology and in proportions of cell types that occur during chronic acclimation to high or low salt diets, and on a cAMP-activated chloride secretion pathway. Recent findings suggesting effects of other hormones on lower intestinal transport are also presented.

Original languageEnglish
Pages (from-to)70-77
Number of pages8
JournalGeneral and Comparative Endocrinology
Volume147
Issue number1
DOIs
Publication statusPublished - 15 May 2006

Other keywords

  • Aldosterone
  • Arginine vasotocin
  • Avian intestine
  • Colon
  • Coprodeum
  • Hen lower intestine
  • Ion transport
  • Low and high salt diets
  • Prolactin

Fingerprint

Dive into the research topics of 'Endocrine regulation of ion transport in the avian lower intestine'. Together they form a unique fingerprint.

Cite this