Elastic modulus and elasticity ratio of malignant breast lesions with shear wave ultrasound elastography: Variations with different region of interest and lesion size

Antonio Bulum; Gordana Ivanac; Eugen Divjak; Iva Biondić Špoljar; Martina Džoić Dominković; Kristina Bojanić; Marko Lucijanić; Boris Brkljačić

doi:10.3390/diagnostics11061015

Elastic modulus and elasticity ratio of malignant breast lesions with shear wave ultrasound elastography: Variations with different region of interest and lesion size

Antonio Bulum^*, Gordana Ivanac, Eugen Divjak, Iva Biondić Špoljar, Martina Džoić Dominković, Kristina Bojanić, Marko Lucijanić, Boris Brkljačić

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Shear wave elastography (SWE) is a type of ultrasound elastography with which the elastic properties of breast tissues can be quantitatively assessed. The purpose of this study was to determine the impact of different regions of interest (ROI) and lesion size on the performance of SWE in differentiating malignant breast lesions. The study included 150 female patients with histopathologically confirmed malignant breast lesions. Minimal (E_min), mean (E_mean), maximal (E_max) elastic modulus and elasticity ratio (e-ratio) values were measured using a circular ROI size of 2, 4 and 6 mm diameters and the lesions were divided into large (diameter ≥ 15 mm) and small (diameter < 15 mm). Highest E_min, E_mean and e-ratio values and lowest variability were observed when using the 2 mm ROI. E_max values did not differ between different ROI sizes. Larger lesions had significantly higher E_mean and E_max values, but there was no difference in e-ratio values between lesions of different sizes. In conclusion, when measuring the E_min, E_mean and e-ratio of malignant breast lesions using SWE the smallest possible ROI size should be used regardless of lesion size. ROI size has no impact on E_max values while lesion size has no impact on e-ratio values.

Original language	English
Article number	1015
Journal	Diagnostics
Volume	11
Issue number	6
DOIs	https://doi.org/10.3390/diagnostics11061015
Publication status	Published - 1 Jun 2021

Bibliographical note

Funding Information:
Funding: This research has been supported by the Croatian Science Foundation under project IP-2016-06-2997 “Sonoelastography and MRI in Diagnosis and Treatment of Breast Cancer”, University of Zagreb School of Medicine, Department of Diagnostic and Interventional Radiology, University Hospital Dubrava, Zagreb (to B.B.).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Other keywords

Breast
Cancer
Elastography
Imaging
Ultrasound

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10.3390/diagnostics11061015

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Bulum, A., Ivanac, G., Divjak, E., Biondić Špoljar, I., Džoić Dominković, M., Bojanić, K., Lucijanić, M., & Brkljačić, B. (2021). Elastic modulus and elasticity ratio of malignant breast lesions with shear wave ultrasound elastography: Variations with different region of interest and lesion size. Diagnostics, 11(6), Article 1015. https://doi.org/10.3390/diagnostics11061015

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title = "Elastic modulus and elasticity ratio of malignant breast lesions with shear wave ultrasound elastography: Variations with different region of interest and lesion size",

abstract = "Shear wave elastography (SWE) is a type of ultrasound elastography with which the elastic properties of breast tissues can be quantitatively assessed. The purpose of this study was to determine the impact of different regions of interest (ROI) and lesion size on the performance of SWE in differentiating malignant breast lesions. The study included 150 female patients with histopathologically confirmed malignant breast lesions. Minimal (Emin), mean (Emean), maximal (Emax) elastic modulus and elasticity ratio (e-ratio) values were measured using a circular ROI size of 2, 4 and 6 mm diameters and the lesions were divided into large (diameter ≥ 15 mm) and small (diameter < 15 mm). Highest Emin, Emean and e-ratio values and lowest variability were observed when using the 2 mm ROI. Emax values did not differ between different ROI sizes. Larger lesions had significantly higher Emean and Emax values, but there was no difference in e-ratio values between lesions of different sizes. In conclusion, when measuring the Emin, Emean and e-ratio of malignant breast lesions using SWE the smallest possible ROI size should be used regardless of lesion size. ROI size has no impact on Emax values while lesion size has no impact on e-ratio values.",

keywords = "Breast, Cancer, Elastography, Imaging, Ultrasound",

author = "Antonio Bulum and Gordana Ivanac and Eugen Divjak and {Biondi{\'c} {\v S}poljar}, Iva and {D{\v z}oi{\'c} Dominkovi{\'c}}, Martina and Kristina Bojani{\'c} and Marko Lucijani{\'c} and Boris Brklja{\v c}i{\'c}",

note = "Funding Information: Funding: This research has been supported by the Croatian Science Foundation under project IP-2016-06-2997 “Sonoelastography and MRI in Diagnosis and Treatment of Breast Cancer”, University of Zagreb School of Medicine, Department of Diagnostic and Interventional Radiology, University Hospital Dubrava, Zagreb (to B.B.). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = jun,

day = "1",

doi = "10.3390/diagnostics11061015",

language = "English",

volume = "11",

journal = "Diagnostics",

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Bulum, A, Ivanac, G, Divjak, E, Biondić Špoljar, I, Džoić Dominković, M, Bojanić, K, Lucijanić, M & Brkljačić, B 2021, 'Elastic modulus and elasticity ratio of malignant breast lesions with shear wave ultrasound elastography: Variations with different region of interest and lesion size', Diagnostics, vol. 11, no. 6, 1015. https://doi.org/10.3390/diagnostics11061015

TY - JOUR

T1 - Elastic modulus and elasticity ratio of malignant breast lesions with shear wave ultrasound elastography

T2 - Variations with different region of interest and lesion size

AU - Bulum, Antonio

AU - Ivanac, Gordana

AU - Divjak, Eugen

AU - Biondić Špoljar, Iva

AU - Džoić Dominković, Martina

AU - Bojanić, Kristina

AU - Lucijanić, Marko

AU - Brkljačić, Boris

N1 - Funding Information: Funding: This research has been supported by the Croatian Science Foundation under project IP-2016-06-2997 “Sonoelastography and MRI in Diagnosis and Treatment of Breast Cancer”, University of Zagreb School of Medicine, Department of Diagnostic and Interventional Radiology, University Hospital Dubrava, Zagreb (to B.B.). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/6/1

Y1 - 2021/6/1

N2 - Shear wave elastography (SWE) is a type of ultrasound elastography with which the elastic properties of breast tissues can be quantitatively assessed. The purpose of this study was to determine the impact of different regions of interest (ROI) and lesion size on the performance of SWE in differentiating malignant breast lesions. The study included 150 female patients with histopathologically confirmed malignant breast lesions. Minimal (Emin), mean (Emean), maximal (Emax) elastic modulus and elasticity ratio (e-ratio) values were measured using a circular ROI size of 2, 4 and 6 mm diameters and the lesions were divided into large (diameter ≥ 15 mm) and small (diameter < 15 mm). Highest Emin, Emean and e-ratio values and lowest variability were observed when using the 2 mm ROI. Emax values did not differ between different ROI sizes. Larger lesions had significantly higher Emean and Emax values, but there was no difference in e-ratio values between lesions of different sizes. In conclusion, when measuring the Emin, Emean and e-ratio of malignant breast lesions using SWE the smallest possible ROI size should be used regardless of lesion size. ROI size has no impact on Emax values while lesion size has no impact on e-ratio values.

AB - Shear wave elastography (SWE) is a type of ultrasound elastography with which the elastic properties of breast tissues can be quantitatively assessed. The purpose of this study was to determine the impact of different regions of interest (ROI) and lesion size on the performance of SWE in differentiating malignant breast lesions. The study included 150 female patients with histopathologically confirmed malignant breast lesions. Minimal (Emin), mean (Emean), maximal (Emax) elastic modulus and elasticity ratio (e-ratio) values were measured using a circular ROI size of 2, 4 and 6 mm diameters and the lesions were divided into large (diameter ≥ 15 mm) and small (diameter < 15 mm). Highest Emin, Emean and e-ratio values and lowest variability were observed when using the 2 mm ROI. Emax values did not differ between different ROI sizes. Larger lesions had significantly higher Emean and Emax values, but there was no difference in e-ratio values between lesions of different sizes. In conclusion, when measuring the Emin, Emean and e-ratio of malignant breast lesions using SWE the smallest possible ROI size should be used regardless of lesion size. ROI size has no impact on Emax values while lesion size has no impact on e-ratio values.

KW - Breast

KW - Cancer

KW - Elastography

KW - Imaging

KW - Ultrasound

UR - http://www.scopus.com/inward/record.url?scp=85108265976&partnerID=8YFLogxK

U2 - 10.3390/diagnostics11061015

DO - 10.3390/diagnostics11061015

M3 - Article

AN - SCOPUS:85108265976

SN - 2075-4418

VL - 11

JO - Diagnostics

JF - Diagnostics

IS - 6

M1 - 1015

ER -

Elastic modulus and elasticity ratio of malignant breast lesions with shear wave ultrasound elastography: Variations with different region of interest and lesion size

Abstract

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