Effects of placental protein 13 on the cardiovascular system in gravid and non-gravid rodents

Sveinbjorn Gizurarson*, Berthold Huppertz, George Osol, Jon Olafur Skarphedinsson, Maurizio Mandala, Hamutal Meiri

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Objectives: Here, we performed a pathophysiological examination of the vascular function of rodent in the presence of placental protein 13 (PP13) and its implication to regulate the development of preeclampsia. Methods: Single i.v. injection and prolonged in vivo exposure to PP13 via osmotic pumps were performed in gravid and non-gravid rats to examine the influence of PP13 on blood pressure and heart rate in animals. The effect of PP13 was also examined in isolated uterine and mesenteric arteries, along with the examination of placental blood supply. Results: Human PP13 has a major impact on the maternal cardiovascular system of rodents by reducing blood pressure, either at single or prolonged exposure, and causing significant vasodilatation in isolated arteries. Prolonged exposure was followed by increased elaboration and angiogenesis of the uteroplacental arteries supplying the placenta. Conclusion: This is the first study describing effects of PP13 on vasodilatation and uterine artery remodeling. The results imply that PP13 may have a physiological role in improving uteroplacental blood flow. The findings of this study make it tempting to speculate that keeping PP13 levels within a certain 'therapeutic window' during pregnancy may facilitate proper adaptation of the maternal vasculature to pregnancy.

Original languageEnglish
Pages (from-to)257-264
Number of pages8
JournalFetal Diagnosis and Therapy
Volume33
Issue number4
DOIs
Publication statusPublished - 2013

Bibliographical note

Publisher Copyright:
Copyright © 2013 S. Karger AG, Basel.

Other keywords

  • Early pregnancy
  • First trimester
  • Galectins
  • Placental protein 13
  • Preeclampsia
  • Vasodilatation

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