Effects of leisure-time physical activity and ventilatory function on risk for stroke in men: the Reykjavík Study.

U Agnarsson, G Thorgeirsson, H Sigvaldason, N Sigfusson

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BACKGROUND: Stroke is a major cause of illness, death, and health expenditures. Leisure-time physical activity may reduce the risk for stroke. OBJECTIVE: To examine the association of leisure-time physical activity and pulmonary function with risk for stroke. DESIGN: Prospective cohort study. SETTING: Reykjavík, Iceland. PARTICIPANTS: 4484 men 45 to 80 years of age followed for a mean (+/-SD) of 10.6 +/- 3.6 years. MEASUREMENTS: Patients underwent physical examination, blood sampling, and spirometry and completed a questionnaire about health and exercise. Computerized hospital records were used to identify strokes, and the Icelandic National Registry was used to identify deaths. RESULTS: New stroke developed in 249 men (5.6%) (hemorrhagic stroke in 44 [18%] and ischemic stroke in 205 [82%]). In a multivariable hazard analysis that controlled for known risk factors for cerebrovascular disease, leisure-time physical activity maintained after 40 years of age was associated with a reduced risk for stroke (relative risk, 0.69 [CI, 0.47 to 1.01] for total stroke and 0.62 [CI, 0.40 to 0.97] for ischemic stroke). Risk for stroke increased with diminished ventilatory function (FVC or FEV1) (relative risk, 1.9 [CI, 1.06 to 3.25] for the lowest compared with the highest quintile). CONCLUSION: Middle-aged men who participate in leisure-time physical activity and have good pulmonary function seem to have a lower risk for stroke than men who are not active or have diminished pulmonary function.
Original languageEnglish
JournalAnnals of Internal Medicine
Publication statusPublished - 15 Jun 1999

Other keywords

  • Cerebrovascular Disorders
  • Follow-Up Studies
  • Forced Expiratory Volume
  • Humans
  • Leisure Activities
  • Lung
  • Male
  • Middle Aged
  • Prospective Studies
  • Questionnaires
  • Risk Factors
  • Spirometry
  • Vital Capacity


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