TY - JOUR
T1 - Effect of lobaric acid on cysteinyl-leukotriene formation and contractile activity of guinea pig taenia coli
AU - Gissurarson, Stefan R.
AU - Sigurdsson, Stefan B.
AU - Wagner, Hildebert
AU - Ingolfsdottir, Kristin
PY - 1997
Y1 - 1997
N2 - Lobaric acid, a constituent of the lichen Stereocaulon alpinum, was investigated for effects on the smooth muscle taenia coli from guinea pigs. Inhibitory effects of iobaric acid on spontaneous contractile activity and on contractile activity stimulated by ionophore A23187 were studied. In addition, the activity of lobaric acid on ionophore-induced generation of cysteinyl-leukotrienes in taenia coli was determined by enzyme immunoassay. Lobaric acid significantly reduced spontaneous contractile activity of the muscle and inhibited contractions caused by ionophore A23187 with an effective dose of 5.8 μM, increased contractility caused by leukotriene D 4 was not influenced by lobaric acid. Lobaric acid inhibited the formation of cysteinyl-leukotrienes as determined by enzyme immunoassay with an effective dose of 5.5 μM.
AB - Lobaric acid, a constituent of the lichen Stereocaulon alpinum, was investigated for effects on the smooth muscle taenia coli from guinea pigs. Inhibitory effects of iobaric acid on spontaneous contractile activity and on contractile activity stimulated by ionophore A23187 were studied. In addition, the activity of lobaric acid on ionophore-induced generation of cysteinyl-leukotrienes in taenia coli was determined by enzyme immunoassay. Lobaric acid significantly reduced spontaneous contractile activity of the muscle and inhibited contractions caused by ionophore A23187 with an effective dose of 5.8 μM, increased contractility caused by leukotriene D 4 was not influenced by lobaric acid. Lobaric acid inhibited the formation of cysteinyl-leukotrienes as determined by enzyme immunoassay with an effective dose of 5.5 μM.
UR - http://www.scopus.com/inward/record.url?scp=0030968515&partnerID=8YFLogxK
M3 - Article
C2 - 9023290
AN - SCOPUS:0030968515
SN - 0022-3565
VL - 280
SP - 770
EP - 773
JO - Journal of Pharmacology and Experimental Therapeutics
JF - Journal of Pharmacology and Experimental Therapeutics
IS - 2
ER -