Early life residence, fish consumption, and risk of breast cancer

Alfheidur Haraldsdottir*, Laufey Steingrimsdottir, Unnur A. Valdimarsdottir, Thor Aspelund, Laufey Tryggvadottir, Tamara B. Harris, Lenore J. Launer, Lorelei A. Mucci, Edward L. Giovannucci, Hans Olov Adami, Vilmundur Gudnason, Johanna E. Torfadottir

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Background: Little is known about fish intake throughout the life course and the risk of breast cancer. Methods: We used data on the first residence of 9,340 women born 1908 to 1935 in the Reykjavik Study as well as food frequency data for different periods of life from a subgroup of the cohort entering the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study (n = 2,882). Results: During a mean follow-up of 27.3 years, 744 women were diagnosed with breast cancer in the Reykjavik Study. An inverse association of breast cancer was observed among women who lived through the puberty period in coastal villages, compared with women residing in the capital area [HR, 0.78; 95% confidence interval (CI), 0.61-0.99]. In the subgroup analysis of this Icelandic population, generally characterized by high fish intake, we found an indication of lower risk of breast cancer among women with high fish consumption (more than 4 portions per week) in adolescence (HR, 0.71; 95% CI, 0.44-1.13) and midlife (HR, 0.46; 95% CI, 0.22-0.97), compared with low consumers (2 portions per week or less). No association was found for fish liver oil consumption in any time period, which could be due to lack of a reference group with low omega-3 fatty acids intake in the study group. Conclusions: Our findings suggest that very high fish consumption in early to midlife may be associated with a reduced risk of breast cancer. Impact: Very high fish consumption in early adulthood to midlife may be associated with decreased risk of breast cancer.

Original languageEnglish
Pages (from-to)346-354
Number of pages9
JournalCancer Epidemiology Biomarkers and Prevention
Volume26
Issue number3
DOIs
Publication statusPublished - 1 Mar 2017

Bibliographical note

Publisher Copyright:
© 2016 American Association for Cancer Research.

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