Does sucralfate prevent short-term NSAID induced damage to the gastroduodenal mucosa?

H Gudjonsson, E Oddsson, B Thjodleifsson

Research output: Contribution to journalArticlepeer-review

Abstract

The objective of the study was to assess whether sucralfate can prevent or diminish short-term nonsteroidal anti-inflammatory drug (NSAID)-induced damage in the stomach and duodenum. Sixteen healthy subjects were randomly treated for 7 days with sucralfate 2 g b.d. or placebo in a double-blind cross-over manner. Naproxen 500 mg b.d. was given on days 3-7. Gastrointestinal endoscopy was performed before and after each treatment period. Mucosal damage was measured by counting erosions, submucosal hemorrhages or ulcers on a fixed point scale of 0-4 for stomach and duodenum separately. The mean posttreatment injury score in the stomach was 2.13 +/- 1.51 and 2.0 +/- 0.97 for the placebo and sucralfate periods, respectively (p = 0.72). The possibility of type II error was 7%. In the duodenum, the injury score was 1.69 +/- 1.08 and 1.06 +/- 0.93 for the placebo and sucralfate periods, respectively (p = 0.08). The possibility of type II error was 37%. Sucralfate has no efficacy as a prophylactic agent against short-term NSAID-induced gastroduodenal injury.
Original languageEnglish
JournalDigestion
DOIs
Publication statusPublished - 1994

Other keywords

  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal
  • Cross-Over Studies
  • Double-Blind Method
  • Drug Interactions
  • Duodenum
  • Female
  • Gastric Mucosa
  • Gastrointestinal Diseases
  • Humans
  • Intestinal Mucosa
  • Male
  • Stomach
  • Sucralfate

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