DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia

Magnus Borssén, Jessica Nordlund, Zahra Haider, Mattias Landfors, Pär Larsson, Jukka Kanerva, Kjeld Schmiegelow, Trond Flaegstad, Ólafur Gísli Jónsson, Britt-Marie Frost, Josefine Palle, Erik Forestier, Mats Heyman, Magnus Hultdin, Gudmar Lönnerholm, Sofie Degerman

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients. METHODS: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1-18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data. RESULTS: Among the 137 patients that later relapsed, patients with a CIMP- profile (n = 42) at initial diagnosis had an inferior overall survival (pOS5years 33%) compared to CIMP+ patients (n = 95, pOS5years 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors. CONCLUSION: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL.
Original languageEnglish
JournalClinical Epigenetics
DOIs
Publication statusPublished - 5 Mar 2018

Other keywords

  • Hvítblæði
  • Börn
  • Sjúkdómshorfur
  • PED12
  • DNA Methylation
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Prognosis
  • Child
  • Minors

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