Different energy metabolite pattern between uterine smooth muscle and striated rectus muscle in term pregnant women

Thóra Steingrímsdóttir, Gunnar Ronquist*, Ulf Ulmsten, Anders Waldenström

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Objective: To study the energy metabolite pattern in term pregnant myometrium and to compare it with that of a striated skeletal muscle. Study design: Metabolites of carbohydrates, triglycerides and nucleotides were determined in biopsies from myometrium and rectus abdominis muscle from ten healthy term pregnant women before onset of labour. The metabolite concentrations in the two types of muscle were compared by two tailed Student's t-test for paired values and correlations were calculated by Pearsson's correlation test. Results: Comparison of the two muscle types revealed a higher concentration of glucose and a higher lactate/pyruvate ratio in the myometrium but a lower concentration of triglyceride metabolites. Adenosine was found in 36-fold higher concentration in the uterine compared with the rectus muscle and an inverse relationship between adenosine and glucose concentrations was observed in the myometrium. Conclusion: The results indicated that the pregnant uterine smooth muscle utilized glucose as the principal nutritive metabolite rather than lipids and that the anaerobic pathway of the glucose metabolism was more active in the myometrium compared with the striated rectus muscle. Also, it is suggested that glucose has a critical role as the principal fuel for ATP formation and the involvement of the adenylate kinase and 5′-nucleotidase reactions in any event of glucose shortage.

Original languageEnglish
Pages (from-to)241-245
Number of pages5
JournalEuropean Journal of Obstetrics and Gynecology
Volume62
Issue number2
DOIs
Publication statusPublished - Oct 1995

Bibliographical note

Funding Information:
This study was supported by grants from the Swedish Medical Research Council (No.17X-03495) and the Medical Faculty, University of Uppsala.

Other keywords

  • Adenosine
  • Glucose
  • Pregnancy
  • Striated muscle
  • Uterus, human

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