Diagnostic accuracy of statistical pattern recognition of electroencephalogram registration in evaluation of cognitive impairment and dementia.

Jon Snaedal, Gisli Holmar Johannesson, Thorkell Eli Gudmundsson, Nicolas Petur Blin, Asdis Lilja Emilsdottir, Bjorn Einarsson, Kristinn Johnsen

Research output: Contribution to journalArticlepeer-review

Abstract

There is still a need for simple, noninvasive, and inexpensive methods to diagnose the causes of cognitive impairment and dementia. In this study, contemporary statistical methods were used to classify the clinical cases of cognitive impairment based on electroencephalograms (EEG). An EEG database was established from seven different groups of subjects with cognitive impairment and dementia as well as healthy controls. A classifier was created for each possible pair of groups using statistical pattern recognition (SPR). A good-to-excellent separation was found when differentiating cases of degenerative disorders from controls, vascular disorders, and depression but this was less so when the likelihood of comorbidity was high. Using EEG with SPR seems to be a reliable method for diagnosing the causes of cognitive impairment and dementia, but comorbidity must be taken into account.
Original languageEnglish
JournalDementia and Geriatric Cognitive Disorders
DOIs
Publication statusPublished - 2012

Other keywords

  • Aged
  • Aged, 80 and over
  • Area Under Curve
  • Dementia
  • Electroencephalography
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Mild Cognitive Impairment
  • Multivariate Analysis
  • Neuropsychological Tests
  • Nortropanes
  • Pattern Recognition, Automated
  • ROC Curve
  • Radiopharmaceuticals
  • Reproducibility of Results
  • Tomography, Emission-Computed, Single-Photon
  • Tomography, X-Ray Computed

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