Decreasing prevalence in cerebral palsy: A multi-site European population-based study, 1980 to 2003

On behalf of surveillance of cerebral palsy network

doi:10.1111/dmcn.12865

Decreasing prevalence in cerebral palsy: A multi-site European population-based study, 1980 to 2003

On behalf of surveillance of cerebral palsy network

Department of Sport Science

Research output: Contribution to journal › Article › peer-review

284 Citations (Scopus)

Abstract

Aim: To monitor the trends in prevalence of cerebral palsy (CP) by birthweight in Europe, 1980 to 2003. Method: Data were collated from 20 population-based registers contributing to the Surveillance of Cerebral Palsy in Europe database. Trend analyses were conducted in four birthweight groups: <1000g (extremely low birthweight [ELBW]); 1000 to 1499g (very low birthweight [VLBW]); 1500 to 2499g (moderately low birthweight [MLBW]); and >2499g (normal birthweight [NBW]). Results: The overall prevalence of CP decreased from 1.90 to 1.77 per 1000 live births, p<0.001, with a mean annual fall of 0.7% (95% confidence interval [CI] -0.3% to -1.0%). Prevalence in NBW children showed a non-significant trend from 1.17 to 0.89 per 1000 live births (p=0.22). Prevalence in MLBW children decreased from 8.5 to 6.2 per 1000 live births (p<0.001), but not linearly. Prevalence in VLBW children also declined from 70.9 to 35.9 per 1000 live births (p<0.001) with a mean annual fall of 3.4% (95% CI -2.4% to -4.3%). Prevalence in ELBW children remained stable, at a mean rate of 42.4 per 1000 live births. Interpretation: The decline in prevalence of CP in children of VLBW continues, and confirms that previously reported. For the first time, there is also a significant decline among those of MLBW, resulting in a significant overall decrease in the prevalence of CP.

Original language	English
Pages (from-to)	85-92
Number of pages	8
Journal	Developmental Medicine and Child Neurology
Volume	58
Issue number	1
DOIs	https://doi.org/10.1111/dmcn.12865
Publication status	Published - 1 Jan 2016

Bibliographical note

Funding Information:
List of SCPE participants: C Cans, M Van Bakel (RHEOP, Grenoble, France), C Arnaud, M Delobel (RHE31, Toulouse, France), J Chalmers (ISDSHS, Edinburgh, UK), V McManus, A Lyons (Lavanagh Centre, Cork, Ireland), J Parkes, H Dolk (Belfast, UK), K Himmelmann, M Pahlman (Göteborg University, Göteborg, Sweden), V Dowding (Dublin, Ireland), A Colver, L Pennington (University of Newcastle, Newcastle, UK), K Horridge (NECCPS, UK), J Kurinczuk, G Surman (NPEU, Oxford, UK), MJ Platt (University of Liverpool, Liverpool, UK), P Udall, G Rackauskaite (NIPH, Copenhagen, Denmark), MG Torrioli, M Marcelli (Lazio Cerebral Palsy Register, Rome, Italy), G Andersen, S Julsen Hollung (CPRN, Tonsberg, Norway), M Bottos (Bologna, Italy), G Gaffney (Galway, Ireland), J De la Cruz, C Pallas (DIMAS-SAMID, Madrid, Spain), D Neubauer, M Jekovec-Vrhov sek (Ljubljana, Slovenia), D Virella, M Andrada (Lisbon, Portugal), A Greitane (Riga, Latvia), K Hollody (Pecs, Hungary), S Sigurdardottir, I Einarsson (Reykjavik, Iceland), M Honold, K Rostasy (Innsbruck, Austria), V Mejaski- Bosnjak (Zagreb, Croatia). This work was supported by grants from the European Commission (SCPE-NET 2008 13 07/ FIB_H120_FY2014 OG). The European Commission had no role in study design, data collection, data analysis, data interpretation, or the writing of the report. The authors have stated that they had no interests that might be perceived as posing a conflict or bias.

Publisher Copyright:
© 2016 Mac Keith Press.

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10.1111/dmcn.12865

Cite this

@article{8b8e84c88b204356a012174195ac5e37,

title = "Decreasing prevalence in cerebral palsy: A multi-site European population-based study, 1980 to 2003",

abstract = "Aim: To monitor the trends in prevalence of cerebral palsy (CP) by birthweight in Europe, 1980 to 2003. Method: Data were collated from 20 population-based registers contributing to the Surveillance of Cerebral Palsy in Europe database. Trend analyses were conducted in four birthweight groups: <1000g (extremely low birthweight [ELBW]); 1000 to 1499g (very low birthweight [VLBW]); 1500 to 2499g (moderately low birthweight [MLBW]); and >2499g (normal birthweight [NBW]). Results: The overall prevalence of CP decreased from 1.90 to 1.77 per 1000 live births, p<0.001, with a mean annual fall of 0.7% (95% confidence interval [CI] -0.3% to -1.0%). Prevalence in NBW children showed a non-significant trend from 1.17 to 0.89 per 1000 live births (p=0.22). Prevalence in MLBW children decreased from 8.5 to 6.2 per 1000 live births (p<0.001), but not linearly. Prevalence in VLBW children also declined from 70.9 to 35.9 per 1000 live births (p<0.001) with a mean annual fall of 3.4% (95% CI -2.4% to -4.3%). Prevalence in ELBW children remained stable, at a mean rate of 42.4 per 1000 live births. Interpretation: The decline in prevalence of CP in children of VLBW continues, and confirms that previously reported. For the first time, there is also a significant decline among those of MLBW, resulting in a significant overall decrease in the prevalence of CP.",

author = "{On behalf of surveillance of cerebral palsy network} and Elodie Sellier and Platt, {Mary Jane} and Andersen, {Guro L.} and Ingeborg Kr{\"a}geloh-Mann and {De La Cruz}, Javier and C. Cans and C. Cans and {Van Bakel}, M. and C. Arnaud and M. Delobel and J. Chalmers and V. McManus and A. Lyons and J. Parkes and H. Dolk and K. Himmelmann and M. Pahlman and V. Dowding and A. Colver and L. Pennington and K. Horridge and J. Kurinczuk and G. Surman and Platt, {M. J.} and P. Udall and G. Rackauskaite and Torrioli, {M. G.} and M. Marcelli and G. Andersen and {Julsen Hollung}, S. and M. Bottos and G. Gaffney and {De la Cruz}, J. and C. Pallas and D. Neubauer and M. Jekovec-Vrhov{\v s}ek and D. Virella and M. Andrada and A. Greitane and K. Hollody and S. Sigurdardottir and I. Einarsson and M. Honold and K. Rostasy and V. Mejaski-Bosnjak",

note = "Funding Information: List of SCPE participants: C Cans, M Van Bakel (RHEOP, Grenoble, France), C Arnaud, M Delobel (RHE31, Toulouse, France), J Chalmers (ISDSHS, Edinburgh, UK), V McManus, A Lyons (Lavanagh Centre, Cork, Ireland), J Parkes, H Dolk (Belfast, UK), K Himmelmann, M Pahlman (G{\"o}teborg University, G{\"o}teborg, Sweden), V Dowding (Dublin, Ireland), A Colver, L Pennington (University of Newcastle, Newcastle, UK), K Horridge (NECCPS, UK), J Kurinczuk, G Surman (NPEU, Oxford, UK), MJ Platt (University of Liverpool, Liverpool, UK), P Udall, G Rackauskaite (NIPH, Copenhagen, Denmark), MG Torrioli, M Marcelli (Lazio Cerebral Palsy Register, Rome, Italy), G Andersen, S Julsen Hollung (CPRN, Tonsberg, Norway), M Bottos (Bologna, Italy), G Gaffney (Galway, Ireland), J De la Cruz, C Pallas (DIMAS-SAMID, Madrid, Spain), D Neubauer, M Jekovec-Vrhov sek (Ljubljana, Slovenia), D Virella, M Andrada (Lisbon, Portugal), A Greitane (Riga, Latvia), K Hollody (Pecs, Hungary), S Sigurdardottir, I Einarsson (Reykjavik, Iceland), M Honold, K Rostasy (Innsbruck, Austria), V Mejaski- Bosnjak (Zagreb, Croatia). This work was supported by grants from the European Commission (SCPE-NET 2008 13 07/ FIB_H120_FY2014 OG). The European Commission had no role in study design, data collection, data analysis, data interpretation, or the writing of the report. The authors have stated that they had no interests that might be perceived as posing a conflict or bias. Publisher Copyright: {\textcopyright} 2016 Mac Keith Press.",

year = "2016",

month = jan,

day = "1",

doi = "10.1111/dmcn.12865",

language = "English",

volume = "58",

pages = "85--92",

journal = "Developmental Medicine and Child Neurology",

issn = "0012-1622",

publisher = "Wiley-Blackwell",

number = "1",

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TY - JOUR

T1 - Decreasing prevalence in cerebral palsy

T2 - A multi-site European population-based study, 1980 to 2003

AU - On behalf of surveillance of cerebral palsy network

AU - Sellier, Elodie

AU - Platt, Mary Jane

AU - Andersen, Guro L.

AU - Krägeloh-Mann, Ingeborg

AU - De La Cruz, Javier

AU - Cans, C.

AU - Van Bakel, M.

AU - Arnaud, C.

AU - Delobel, M.

AU - Chalmers, J.

AU - McManus, V.

AU - Lyons, A.

AU - Parkes, J.

AU - Dolk, H.

AU - Himmelmann, K.

AU - Pahlman, M.

AU - Dowding, V.

AU - Colver, A.

AU - Pennington, L.

AU - Horridge, K.

AU - Kurinczuk, J.

AU - Surman, G.

AU - Platt, M. J.

AU - Udall, P.

AU - Rackauskaite, G.

AU - Torrioli, M. G.

AU - Marcelli, M.

AU - Andersen, G.

AU - Julsen Hollung, S.

AU - Bottos, M.

AU - Gaffney, G.

AU - De la Cruz, J.

AU - Pallas, C.

AU - Neubauer, D.

AU - Jekovec-Vrhovšek, M.

AU - Virella, D.

AU - Andrada, M.

AU - Greitane, A.

AU - Hollody, K.

AU - Sigurdardottir, S.

AU - Einarsson, I.

AU - Honold, M.

AU - Rostasy, K.

AU - Mejaski-Bosnjak, V.

N1 - Funding Information: List of SCPE participants: C Cans, M Van Bakel (RHEOP, Grenoble, France), C Arnaud, M Delobel (RHE31, Toulouse, France), J Chalmers (ISDSHS, Edinburgh, UK), V McManus, A Lyons (Lavanagh Centre, Cork, Ireland), J Parkes, H Dolk (Belfast, UK), K Himmelmann, M Pahlman (Göteborg University, Göteborg, Sweden), V Dowding (Dublin, Ireland), A Colver, L Pennington (University of Newcastle, Newcastle, UK), K Horridge (NECCPS, UK), J Kurinczuk, G Surman (NPEU, Oxford, UK), MJ Platt (University of Liverpool, Liverpool, UK), P Udall, G Rackauskaite (NIPH, Copenhagen, Denmark), MG Torrioli, M Marcelli (Lazio Cerebral Palsy Register, Rome, Italy), G Andersen, S Julsen Hollung (CPRN, Tonsberg, Norway), M Bottos (Bologna, Italy), G Gaffney (Galway, Ireland), J De la Cruz, C Pallas (DIMAS-SAMID, Madrid, Spain), D Neubauer, M Jekovec-Vrhov sek (Ljubljana, Slovenia), D Virella, M Andrada (Lisbon, Portugal), A Greitane (Riga, Latvia), K Hollody (Pecs, Hungary), S Sigurdardottir, I Einarsson (Reykjavik, Iceland), M Honold, K Rostasy (Innsbruck, Austria), V Mejaski- Bosnjak (Zagreb, Croatia). This work was supported by grants from the European Commission (SCPE-NET 2008 13 07/ FIB_H120_FY2014 OG). The European Commission had no role in study design, data collection, data analysis, data interpretation, or the writing of the report. The authors have stated that they had no interests that might be perceived as posing a conflict or bias. Publisher Copyright: © 2016 Mac Keith Press.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Aim: To monitor the trends in prevalence of cerebral palsy (CP) by birthweight in Europe, 1980 to 2003. Method: Data were collated from 20 population-based registers contributing to the Surveillance of Cerebral Palsy in Europe database. Trend analyses were conducted in four birthweight groups: <1000g (extremely low birthweight [ELBW]); 1000 to 1499g (very low birthweight [VLBW]); 1500 to 2499g (moderately low birthweight [MLBW]); and >2499g (normal birthweight [NBW]). Results: The overall prevalence of CP decreased from 1.90 to 1.77 per 1000 live births, p<0.001, with a mean annual fall of 0.7% (95% confidence interval [CI] -0.3% to -1.0%). Prevalence in NBW children showed a non-significant trend from 1.17 to 0.89 per 1000 live births (p=0.22). Prevalence in MLBW children decreased from 8.5 to 6.2 per 1000 live births (p<0.001), but not linearly. Prevalence in VLBW children also declined from 70.9 to 35.9 per 1000 live births (p<0.001) with a mean annual fall of 3.4% (95% CI -2.4% to -4.3%). Prevalence in ELBW children remained stable, at a mean rate of 42.4 per 1000 live births. Interpretation: The decline in prevalence of CP in children of VLBW continues, and confirms that previously reported. For the first time, there is also a significant decline among those of MLBW, resulting in a significant overall decrease in the prevalence of CP.

AB - Aim: To monitor the trends in prevalence of cerebral palsy (CP) by birthweight in Europe, 1980 to 2003. Method: Data were collated from 20 population-based registers contributing to the Surveillance of Cerebral Palsy in Europe database. Trend analyses were conducted in four birthweight groups: <1000g (extremely low birthweight [ELBW]); 1000 to 1499g (very low birthweight [VLBW]); 1500 to 2499g (moderately low birthweight [MLBW]); and >2499g (normal birthweight [NBW]). Results: The overall prevalence of CP decreased from 1.90 to 1.77 per 1000 live births, p<0.001, with a mean annual fall of 0.7% (95% confidence interval [CI] -0.3% to -1.0%). Prevalence in NBW children showed a non-significant trend from 1.17 to 0.89 per 1000 live births (p=0.22). Prevalence in MLBW children decreased from 8.5 to 6.2 per 1000 live births (p<0.001), but not linearly. Prevalence in VLBW children also declined from 70.9 to 35.9 per 1000 live births (p<0.001) with a mean annual fall of 3.4% (95% CI -2.4% to -4.3%). Prevalence in ELBW children remained stable, at a mean rate of 42.4 per 1000 live births. Interpretation: The decline in prevalence of CP in children of VLBW continues, and confirms that previously reported. For the first time, there is also a significant decline among those of MLBW, resulting in a significant overall decrease in the prevalence of CP.

UR - http://www.scopus.com/inward/record.url?scp=84955183799&partnerID=8YFLogxK

U2 - 10.1111/dmcn.12865

DO - 10.1111/dmcn.12865

M3 - Article

C2 - 26330098

AN - SCOPUS:84955183799

SN - 0012-1622

VL - 58

SP - 85

EP - 92

JO - Developmental Medicine and Child Neurology

JF - Developmental Medicine and Child Neurology

IS - 1

ER -

Decreasing prevalence in cerebral palsy: A multi-site European population-based study, 1980 to 2003

Abstract

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